Systems Biology of Metabolism: A Driver for Developing Personalized and Precision Medicine

Jens Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

352 Downloads (Pure)


Systems biology uses mathematical models to analyze large datasets and simulate system behavior. It enables integrative analysis of different types of data and can thereby provide new insight into complex biological systems. Here will be discussed the challenges of using systems medicine for advancing the development of personalized and precision medicine to treat metabolic diseases like insulin resistance, obesity, NAFLD, NASH, and cancer. It will be illustrated how the concept of genome-scale metabolic models can be used for integrative analysis of big data with the objective of identifying novel biomarkers that are foundational for personalized and precision medicine.
Original languageEnglish
JournalCell Metabolism
Issue number3
Pages (from-to)572-579
Number of pages8
Publication statusPublished - 2017

Bibliographical note

Open Archive under an Elsevier user license. Elsevier enables subscribers and the general public to have free access to archived material in 113 Elsevier journals. Articles featured in the archives are free for everyone to read and download and are made available after an embargo period


Dive into the research topics of 'Systems Biology of Metabolism: A Driver for Developing Personalized and Precision Medicine'. Together they form a unique fingerprint.

Cite this