Systems Biology of Metabolism: A Driver for Developing Personalized and Precision Medicine

Jens Nielsen

Research output: Contribution to journalJournal articlepeer-review

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Abstract

Systems biology uses mathematical models to analyze large datasets and simulate system behavior. It enables integrative analysis of different types of data and can thereby provide new insight into complex biological systems. Here will be discussed the challenges of using systems medicine for advancing the development of personalized and precision medicine to treat metabolic diseases like insulin resistance, obesity, NAFLD, NASH, and cancer. It will be illustrated how the concept of genome-scale metabolic models can be used for integrative analysis of big data with the objective of identifying novel biomarkers that are foundational for personalized and precision medicine.
Original languageEnglish
JournalCell Metabolism
Volume25
Issue number3
Pages (from-to)572-579
Number of pages8
ISSN1550-4131
DOIs
Publication statusPublished - 2017

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