Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

Kyu-Sang Hwang, Hyun Uk Kim, Pep Charusanti, Bernhard Palsson, Sang Yup Lee

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Streptomyces species continue to attract attention as a source of novel medicinal compounds. Despite a long history of studies on these microorganisms, they still have many biochemical mysteries to be elucidated. Investigations of novel secondary metabolites and their biosynthetic gene clusters have been more systematized with high-throughput techniques through inspections of correlations among components of the primary and secondary metabolisms at the genome scale. Moreover, up-to-date information on the genome of Streptomyces species with emphasis on their secondary metabolism has been collected in the form of databases and knowledgebases, providing predictive information and enabling one to explore experimentally unrecognized biological spaces of secondary metabolism. Herein, we review recent trends in the systems biology and biotechnology of Streptomyces species.
Original languageEnglish
JournalBiotechnology Advances
Volume32
Issue number2
Pages (from-to)255-268
ISSN0734-9750
DOIs
Publication statusPublished - 2014

Keywords

  • Streptomyces species
  • Secondary metabolites
  • Systems biology
  • Systems biotechnology
  • Systems metabolic engineering
  • Omics techniques
  • Databases
  • Knowledgebases
  • Constraint-based flux analysis

Cite this

@article{8aae3a6b3a2f461c823c390bb327bf3c,
title = "Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites",
abstract = "Streptomyces species continue to attract attention as a source of novel medicinal compounds. Despite a long history of studies on these microorganisms, they still have many biochemical mysteries to be elucidated. Investigations of novel secondary metabolites and their biosynthetic gene clusters have been more systematized with high-throughput techniques through inspections of correlations among components of the primary and secondary metabolisms at the genome scale. Moreover, up-to-date information on the genome of Streptomyces species with emphasis on their secondary metabolism has been collected in the form of databases and knowledgebases, providing predictive information and enabling one to explore experimentally unrecognized biological spaces of secondary metabolism. Herein, we review recent trends in the systems biology and biotechnology of Streptomyces species.",
keywords = "Streptomyces species, Secondary metabolites, Systems biology, Systems biotechnology, Systems metabolic engineering, Omics techniques, Databases, Knowledgebases, Constraint-based flux analysis",
author = "Kyu-Sang Hwang and Kim, {Hyun Uk} and Pep Charusanti and Bernhard Palsson and {Yup Lee}, Sang",
year = "2014",
doi = "10.1016/j.biotechadv.2013.10.008",
language = "English",
volume = "32",
pages = "255--268",
journal = "Biotechnology Advances",
issn = "0734-9750",
publisher = "Elsevier",
number = "2",

}

Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites. / Hwang, Kyu-Sang; Kim, Hyun Uk; Charusanti, Pep; Palsson, Bernhard; Yup Lee, Sang.

In: Biotechnology Advances, Vol. 32, No. 2, 2014, p. 255-268.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

AU - Hwang, Kyu-Sang

AU - Kim, Hyun Uk

AU - Charusanti, Pep

AU - Palsson, Bernhard

AU - Yup Lee, Sang

PY - 2014

Y1 - 2014

N2 - Streptomyces species continue to attract attention as a source of novel medicinal compounds. Despite a long history of studies on these microorganisms, they still have many biochemical mysteries to be elucidated. Investigations of novel secondary metabolites and their biosynthetic gene clusters have been more systematized with high-throughput techniques through inspections of correlations among components of the primary and secondary metabolisms at the genome scale. Moreover, up-to-date information on the genome of Streptomyces species with emphasis on their secondary metabolism has been collected in the form of databases and knowledgebases, providing predictive information and enabling one to explore experimentally unrecognized biological spaces of secondary metabolism. Herein, we review recent trends in the systems biology and biotechnology of Streptomyces species.

AB - Streptomyces species continue to attract attention as a source of novel medicinal compounds. Despite a long history of studies on these microorganisms, they still have many biochemical mysteries to be elucidated. Investigations of novel secondary metabolites and their biosynthetic gene clusters have been more systematized with high-throughput techniques through inspections of correlations among components of the primary and secondary metabolisms at the genome scale. Moreover, up-to-date information on the genome of Streptomyces species with emphasis on their secondary metabolism has been collected in the form of databases and knowledgebases, providing predictive information and enabling one to explore experimentally unrecognized biological spaces of secondary metabolism. Herein, we review recent trends in the systems biology and biotechnology of Streptomyces species.

KW - Streptomyces species

KW - Secondary metabolites

KW - Systems biology

KW - Systems biotechnology

KW - Systems metabolic engineering

KW - Omics techniques

KW - Databases

KW - Knowledgebases

KW - Constraint-based flux analysis

U2 - 10.1016/j.biotechadv.2013.10.008

DO - 10.1016/j.biotechadv.2013.10.008

M3 - Journal article

VL - 32

SP - 255

EP - 268

JO - Biotechnology Advances

JF - Biotechnology Advances

SN - 0734-9750

IS - 2

ER -