Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

Kyu-Sang Hwang, Hyun Uk Kim, Pep Charusanti, Bernhard Palsson, Sang Yup Lee

Research output: Contribution to journalJournal articleResearchpeer-review


Streptomyces species continue to attract attention as a source of novel medicinal compounds. Despite a long history of studies on these microorganisms, they still have many biochemical mysteries to be elucidated. Investigations of novel secondary metabolites and their biosynthetic gene clusters have been more systematized with high-throughput techniques through inspections of correlations among components of the primary and secondary metabolisms at the genome scale. Moreover, up-to-date information on the genome of Streptomyces species with emphasis on their secondary metabolism has been collected in the form of databases and knowledgebases, providing predictive information and enabling one to explore experimentally unrecognized biological spaces of secondary metabolism. Herein, we review recent trends in the systems biology and biotechnology of Streptomyces species.
Original languageEnglish
JournalBiotechnology Advances
Issue number2
Pages (from-to)255-268
Publication statusPublished - 2014


  • Streptomyces species
  • Secondary metabolites
  • Systems biology
  • Systems biotechnology
  • Systems metabolic engineering
  • Omics techniques
  • Databases
  • Knowledgebases
  • Constraint-based flux analysis

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