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DOI

  • Author: Bongers, Mareike

    University of Queensland

  • Author: Chrysanthopoulos, Panagiotis K.

    University of Queensland, Australia

  • Author: Behrendorff, James B. Y. H.

    University of Queensland, Australia

  • Author: Hodson, Mark P.

    University of Queensland, Australia

  • Author: Vickers, Claudia E.

    University of Queensland, Australia

  • Author: Nielsen, Lars K.

    University of Queensland, Australia

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High-throughput screening methods assume that the output measured is representative of changes in metabolic flux toward the desired product and is not affected by secondary phenotypes. However, metabolic engineering can result in unintended phenotypes that may go unnoticed in initial screening. The red pigment lycopene, a carotenoid with antioxidant properties, has been used as a reporter of isoprenoid pathway flux in metabolic engineering for over a decade. Lycopene production is known to vary between wild-type Escherichia coli hosts, but the reasons behind this variation have never been fully elucidated.
Original languageEnglish
Article number193
JournalMicrobial Cell Factories
Volume14
Number of pages16
ISSN1475-2859
DOIs
Publication statusPublished - 2015
Externally publishedYes
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Isoprenoids, Lycopene, Methylerythritol phosphate pathway, RpoS, ROS, Escherichia coli, Oxidative stress

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