Systems analysis of host-parasite interactions

Justine Swann, Neema Jamshidi, Nathan E. Lewis, Elizabeth A. Winzeler

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Parasitic diseases caused by protozoan pathogens lead to hundreds of thousands of deaths per year in addition to substantial suffering and socioeconomic decline for millions of people worldwide. The lack of effective vaccines coupled with the widespread emergence of drug-resistant parasites necessitates that the research community take an active role in understanding host-parasite infection biology in order to develop improved therapeutics. Recent advances in next-generation sequencing and the rapid development of publicly accessible genomic databases for many human pathogens have facilitated the application of systems biology to the study of host-parasite interactions. Over the past decade, these technologies have led to the discovery of many important biological processes governing parasitic disease. The integration and interpretation of high-throughput -omic data will undoubtedly generate extraordinary insight into host-parasite interaction networks essential to navigate the intricacies of these complex systems. As systems analysis continues to build the foundation for our understanding of host-parasite biology, this will provide the framework necessary to drive drug discovery research forward and accelerate the development of new antiparasitic therapies. WIREs Syst Biol Med 2015, 7:381-400. doi: 10.1002/wsbm.1311 For further resources related to this article, please visit the .
Original languageEnglish
JournalWiley Interdisciplinary Reviews. Systems Biology and Medicine (Online)
Issue number6
Pages (from-to)381-400
Number of pages20
Publication statusPublished - 2015
Externally publishedYes

Bibliographical note

© 2015 The Authors. WIREs Systems Biology and Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.


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