System-Level Sensitivity Analysis of SiNW-bioFET-Based Biosensing Using Lockin Amplification

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Abstract

Although Silicon Nanowire biological Field-Effect Transistors (SiNW-bioFETs) have steadily demonstrated their ability to detect biological markers at ultra-low concentration, they have not yet translated into routine diagnostics applications. One of the challenges inherent to the technology is that it requires an instrumentation capable of recovering ultra-low signal variations from sensors usually designed and operated in a highly-resistive configuration. Often overlooked, the SiNWbioFET/ instrument interactions are yet critical factors in determining overall system biodetection performances. Here, we carry out for the first time the system-level sensitivity analysis of a generic SiNW-bioFET model coupled to a custom-design instrument based on the lock-in amplifier. By investigating a large parametric space spanning over both sensor and instrumentation specifications, we demonstrate that systemwide investigations can be instrumental in identifying the design trade-offs that will ensure the lowest Limits-of-Detection. The generic character of our analytical model allows us to elaborate on the most general SiNW-bioFET/instrument interactions and their overall implications on detection performances. Our model can be adapted to better match specific sensor or instrument designs to either ensure that ultra-high sensitivity SiNW-bioFETs are coupled with an appropriately sensitive and noise-rejecting instrumentation, or to best tailor SiNW-bioFET design to the specifications of an existing instrument.
Original languageEnglish
JournalI E E E Sensors Journal
Volume17
Issue number19
Pages (from-to)6295-6311
ISSN1530-437X
DOIs
Publication statusPublished - 2017

Cite this

@article{957c8c6edc49435ca5c25c725e90e4e6,
title = "System-Level Sensitivity Analysis of SiNW-bioFET-Based Biosensing Using Lockin Amplification",
abstract = "Although Silicon Nanowire biological Field-Effect Transistors (SiNW-bioFETs) have steadily demonstrated their ability to detect biological markers at ultra-low concentration, they have not yet translated into routine diagnostics applications. One of the challenges inherent to the technology is that it requires an instrumentation capable of recovering ultra-low signal variations from sensors usually designed and operated in a highly-resistive configuration. Often overlooked, the SiNWbioFET/ instrument interactions are yet critical factors in determining overall system biodetection performances. Here, we carry out for the first time the system-level sensitivity analysis of a generic SiNW-bioFET model coupled to a custom-design instrument based on the lock-in amplifier. By investigating a large parametric space spanning over both sensor and instrumentation specifications, we demonstrate that systemwide investigations can be instrumental in identifying the design trade-offs that will ensure the lowest Limits-of-Detection. The generic character of our analytical model allows us to elaborate on the most general SiNW-bioFET/instrument interactions and their overall implications on detection performances. Our model can be adapted to better match specific sensor or instrument designs to either ensure that ultra-high sensitivity SiNW-bioFETs are coupled with an appropriately sensitive and noise-rejecting instrumentation, or to best tailor SiNW-bioFET design to the specifications of an existing instrument.",
author = "Fran{\cc}ois Patou and Maria Dimaki and Claus Kj{\ae}rgaard and Jan Madsen and Svendsen, {Winnie Edith}",
year = "2017",
doi = "10.1109/JSEN.2017.2742018",
language = "English",
volume = "17",
pages = "6295--6311",
journal = "I E E E Sensors Journal",
issn = "1530-437X",
publisher = "Institute of Electrical and Electronics Engineers",
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}

System-Level Sensitivity Analysis of SiNW-bioFET-Based Biosensing Using Lockin Amplification. / Patou, François; Dimaki, Maria; Kjærgaard, Claus; Madsen, Jan; Svendsen, Winnie Edith.

In: I E E E Sensors Journal, Vol. 17, No. 19, 2017, p. 6295-6311.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - System-Level Sensitivity Analysis of SiNW-bioFET-Based Biosensing Using Lockin Amplification

AU - Patou, François

AU - Dimaki, Maria

AU - Kjærgaard, Claus

AU - Madsen, Jan

AU - Svendsen, Winnie Edith

PY - 2017

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N2 - Although Silicon Nanowire biological Field-Effect Transistors (SiNW-bioFETs) have steadily demonstrated their ability to detect biological markers at ultra-low concentration, they have not yet translated into routine diagnostics applications. One of the challenges inherent to the technology is that it requires an instrumentation capable of recovering ultra-low signal variations from sensors usually designed and operated in a highly-resistive configuration. Often overlooked, the SiNWbioFET/ instrument interactions are yet critical factors in determining overall system biodetection performances. Here, we carry out for the first time the system-level sensitivity analysis of a generic SiNW-bioFET model coupled to a custom-design instrument based on the lock-in amplifier. By investigating a large parametric space spanning over both sensor and instrumentation specifications, we demonstrate that systemwide investigations can be instrumental in identifying the design trade-offs that will ensure the lowest Limits-of-Detection. The generic character of our analytical model allows us to elaborate on the most general SiNW-bioFET/instrument interactions and their overall implications on detection performances. Our model can be adapted to better match specific sensor or instrument designs to either ensure that ultra-high sensitivity SiNW-bioFETs are coupled with an appropriately sensitive and noise-rejecting instrumentation, or to best tailor SiNW-bioFET design to the specifications of an existing instrument.

AB - Although Silicon Nanowire biological Field-Effect Transistors (SiNW-bioFETs) have steadily demonstrated their ability to detect biological markers at ultra-low concentration, they have not yet translated into routine diagnostics applications. One of the challenges inherent to the technology is that it requires an instrumentation capable of recovering ultra-low signal variations from sensors usually designed and operated in a highly-resistive configuration. Often overlooked, the SiNWbioFET/ instrument interactions are yet critical factors in determining overall system biodetection performances. Here, we carry out for the first time the system-level sensitivity analysis of a generic SiNW-bioFET model coupled to a custom-design instrument based on the lock-in amplifier. By investigating a large parametric space spanning over both sensor and instrumentation specifications, we demonstrate that systemwide investigations can be instrumental in identifying the design trade-offs that will ensure the lowest Limits-of-Detection. The generic character of our analytical model allows us to elaborate on the most general SiNW-bioFET/instrument interactions and their overall implications on detection performances. Our model can be adapted to better match specific sensor or instrument designs to either ensure that ultra-high sensitivity SiNW-bioFETs are coupled with an appropriately sensitive and noise-rejecting instrumentation, or to best tailor SiNW-bioFET design to the specifications of an existing instrument.

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DO - 10.1109/JSEN.2017.2742018

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