Synthetic methyl hexagalacturonate hapten inhibitors of antihomogalacturonan monoclonal antibodies LM7, JIM5 and JIM7

Mads Hartvig Clausen; William George Tycho Willats; J. Paul Knox

doi:10.1016/S0008-6215(03)00272-6

Synthetic methyl hexagalacturonate hapten inhibitors of antihomogalacturonan monoclonal antibodies LM7, JIM5 and JIM7

Mads Hartvig Clausen, William George Tycho Willats, J. Paul Knox

Department of Chemistry

University of Leeds

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A range of synthetic methyl hexagalacturonates were used as potential hapten inhibitors in competitive-inhibition enzyme-linked immunosorbent assays (ELISAs) with anti-homogalacturonan monoclonal antibodies LM7, JIM5 and JIM7. The selective inhibition of these antibodies by different haptens provides insight into the structures of the partially methyl-esterified pectin epitopes of these widely used monoclonal antibodies.

Original language	English
Journal	Carbohydrate Research
Volume	338
Issue number	17
Pages (from-to)	1797-1800
ISSN	0008-6215
DOIs	https://doi.org/10.1016/S0008-6215(03)00272-6
Publication status	Published - 2003

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title = "Synthetic methyl hexagalacturonate hapten inhibitors of antihomogalacturonan monoclonal antibodies LM7, JIM5 and JIM7",

abstract = "A range of synthetic methyl hexagalacturonates were used as potential hapten inhibitors in competitive-inhibition enzyme-linked immunosorbent assays (ELISAs) with anti-homogalacturonan monoclonal antibodies LM7, JIM5 and JIM7. The selective inhibition of these antibodies by different haptens provides insight into the structures of the partially methyl-esterified pectin epitopes of these widely used monoclonal antibodies.",

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AU - Clausen, Mads Hartvig

AU - Willats, William George Tycho

AU - Knox, J. Paul

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N2 - A range of synthetic methyl hexagalacturonates were used as potential hapten inhibitors in competitive-inhibition enzyme-linked immunosorbent assays (ELISAs) with anti-homogalacturonan monoclonal antibodies LM7, JIM5 and JIM7. The selective inhibition of these antibodies by different haptens provides insight into the structures of the partially methyl-esterified pectin epitopes of these widely used monoclonal antibodies.

AB - A range of synthetic methyl hexagalacturonates were used as potential hapten inhibitors in competitive-inhibition enzyme-linked immunosorbent assays (ELISAs) with anti-homogalacturonan monoclonal antibodies LM7, JIM5 and JIM7. The selective inhibition of these antibodies by different haptens provides insight into the structures of the partially methyl-esterified pectin epitopes of these widely used monoclonal antibodies.

U2 - 10.1016/S0008-6215(03)00272-6

DO - 10.1016/S0008-6215(03)00272-6

M3 - Journal article

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JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 17

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Synthetic methyl hexagalacturonate hapten inhibitors of antihomogalacturonan monoclonal antibodies LM7, JIM5 and JIM7

Abstract

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