Synthetic Biology of Yeast

Zihe Liu, Yueping Zhang, Jens Nielsen*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review


With the rapid development of DNA synthesis and next-generation sequencing, synthetic biology that aims to standardize, modularize, and innovate cellular functions, has achieved vast progress. Here we review key advances in synthetic biology of the yeast Saccharomyces cerevisiae, which serves as an important eukaryal model organism and widely applied cell factory. This covers the development of new building blocks, i.e., promoters, terminators and enzymes, pathway engineering, tools developments, and gene circuits utilization. We will also summarize impacts of synthetic biology on both basic and applied biology, and end with further directions for advancing synthetic biology in yeast.

Original languageEnglish
Issue number11
Pages (from-to)1511-1520
Publication statusPublished - 19 Mar 2019

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