Synthetic Biology of Yeast

Zihe Liu, Yueping Zhang, Jens Nielsen*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

Abstract

With the rapid development of DNA synthesis and next-generation sequencing, synthetic biology that aims to standardize, modularize, and innovate cellular functions, has achieved vast progress. Here we review key advances in synthetic biology of the yeast Saccharomyces cerevisiae, which serves as an important eukaryal model organism and widely applied cell factory. This covers the development of new building blocks, i.e., promoters, terminators and enzymes, pathway engineering, tools developments, and gene circuits utilization. We will also summarize impacts of synthetic biology on both basic and applied biology, and end with further directions for advancing synthetic biology in yeast.

Original languageEnglish
JournalBiochemistry
Volume58
Issue number11
Pages (from-to)1511-1520
ISSN0006-2960
DOIs
Publication statusPublished - 19 Mar 2019

Cite this

Liu, Zihe ; Zhang, Yueping ; Nielsen, Jens. / Synthetic Biology of Yeast. In: Biochemistry. 2019 ; Vol. 58, No. 11. pp. 1511-1520.
@article{f2253c239539466e882d072289044c34,
title = "Synthetic Biology of Yeast",
abstract = "With the rapid development of DNA synthesis and next-generation sequencing, synthetic biology that aims to standardize, modularize, and innovate cellular functions, has achieved vast progress. Here we review key advances in synthetic biology of the yeast Saccharomyces cerevisiae, which serves as an important eukaryal model organism and widely applied cell factory. This covers the development of new building blocks, i.e., promoters, terminators and enzymes, pathway engineering, tools developments, and gene circuits utilization. We will also summarize impacts of synthetic biology on both basic and applied biology, and end with further directions for advancing synthetic biology in yeast.",
author = "Zihe Liu and Yueping Zhang and Jens Nielsen",
year = "2019",
month = "3",
day = "19",
doi = "10.1021/acs.biochem.8b01236",
language = "English",
volume = "58",
pages = "1511--1520",
journal = "Biochemistry",
issn = "0006-2960",
publisher = "American Chemical Society",
number = "11",

}

Synthetic Biology of Yeast. / Liu, Zihe; Zhang, Yueping; Nielsen, Jens.

In: Biochemistry, Vol. 58, No. 11, 19.03.2019, p. 1511-1520.

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

T1 - Synthetic Biology of Yeast

AU - Liu, Zihe

AU - Zhang, Yueping

AU - Nielsen, Jens

PY - 2019/3/19

Y1 - 2019/3/19

N2 - With the rapid development of DNA synthesis and next-generation sequencing, synthetic biology that aims to standardize, modularize, and innovate cellular functions, has achieved vast progress. Here we review key advances in synthetic biology of the yeast Saccharomyces cerevisiae, which serves as an important eukaryal model organism and widely applied cell factory. This covers the development of new building blocks, i.e., promoters, terminators and enzymes, pathway engineering, tools developments, and gene circuits utilization. We will also summarize impacts of synthetic biology on both basic and applied biology, and end with further directions for advancing synthetic biology in yeast.

AB - With the rapid development of DNA synthesis and next-generation sequencing, synthetic biology that aims to standardize, modularize, and innovate cellular functions, has achieved vast progress. Here we review key advances in synthetic biology of the yeast Saccharomyces cerevisiae, which serves as an important eukaryal model organism and widely applied cell factory. This covers the development of new building blocks, i.e., promoters, terminators and enzymes, pathway engineering, tools developments, and gene circuits utilization. We will also summarize impacts of synthetic biology on both basic and applied biology, and end with further directions for advancing synthetic biology in yeast.

U2 - 10.1021/acs.biochem.8b01236

DO - 10.1021/acs.biochem.8b01236

M3 - Review

VL - 58

SP - 1511

EP - 1520

JO - Biochemistry

JF - Biochemistry

SN - 0006-2960

IS - 11

ER -