Synthesis of the macrocyclic core of (-)-pladienolide B

Philip Robert Skaanderup, T. Jensen

Research output: Contribution to journalJournal articleResearchpeer-review


An efficient synthesis of the macrocyclic core of (-)-pladienolide B is disclosed. The concise route relies on a chiral auxiliary-mediated asymmetric aldol addition and an osmium-catalyzed asymmetric dihydroxylation to install the three oxygenated stereocenters of the macrocycle. This purely reagent-controlled and flexible strategy sets the stage for future analogue syntheses and structure-activity relationship plotting of the appealing anticancer lead structure pladienolide B.
Original languageEnglish
JournalOrganic Letters
Issue number13
Pages (from-to)2821-2824
Publication statusPublished - 2008


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