Synthesis of sp3-rich scaffolds for molecular libraries through complexity-generating cascade reactions

Thomas Flagstad, Geanna Min, K. Bonnet, R. Morgentin, D. Roche, Mads Hartvig Clausen, Thomas Eiland Nielsen

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Abstract

An efficient strategy for the synthesis of complex small molecules from simple building blocks is presented. Key steps of the strategy include tandem Petasis and Diels–Alder reactions, and divergent complexity-generating cyclization cascades from a key dialdehyde intermediate. The methodology is validated through the synthesis of a representative compound set, which has been used in the production of 1617 molecules for the European Lead Factory.
Original languageEnglish
JournalOrganic & Biomolecular Chemistry
Volume14
Issue number21
Pages (from-to)4943-4946
ISSN1477-0520
DOIs
Publication statusPublished - 2016

Bibliographical note

This article is published Open Access as part of the RSC's Gold for Gold initiative, licensed under a Creative Commons Attribution 3.0 Unported Licence.

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