Synthesis of sp3-rich scaffolds for molecular libraries through complexity-generating cascade reactions

Thomas Flagstad; Geanna Min; K. Bonnet; R.  Morgentin; D.  Roche; Mads Hartvig Clausen; Thomas Eiland Nielsen

doi:10.1039/c6ob00961a

Synthesis of sp3-rich scaffolds for molecular libraries through complexity-generating cascade reactions

Thomas Flagstad, Geanna Min, K. Bonnet, R. Morgentin, D. Roche, Mads Hartvig Clausen, Thomas Eiland Nielsen

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

649 Downloads (Pure)

Abstract

An efficient strategy for the synthesis of complex small molecules from simple building blocks is presented. Key steps of the strategy include tandem Petasis and Diels–Alder reactions, and divergent complexity-generating cyclization cascades from a key dialdehyde intermediate. The methodology is validated through the synthesis of a representative compound set, which has been used in the production of 1617 molecules for the European Lead Factory.

Original language	English
Journal	Organic & Biomolecular Chemistry
Volume	14
Issue number	21
Pages (from-to)	4943-4946
ISSN	1477-0520
DOIs	https://doi.org/10.1039/c6ob00961a
Publication status	Published - 2016

Bibliographical note

This article is published Open Access as part of the RSC's Gold for Gold initiative, licensed under a Creative Commons Attribution 3.0 Unported Licence.

Access to Document

10.1039/c6ob00961a

C6ob00961aFinal published version, 1.09 MB

OpenUrl availability

Full text

Cite this

@article{5a6841429cb9481091ac8f369607e54d,

title = "Synthesis of sp3-rich scaffolds for molecular libraries through complexity-generating cascade reactions",

abstract = "An efficient strategy for the synthesis of complex small molecules from simple building blocks is presented. Key steps of the strategy include tandem Petasis and Diels–Alder reactions, and divergent complexity-generating cyclization cascades from a key dialdehyde intermediate. The methodology is validated through the synthesis of a representative compound set, which has been used in the production of 1617 molecules for the European Lead Factory.",

author = "Thomas Flagstad and Geanna Min and K. Bonnet and R. Morgentin and D. Roche and Clausen, {Mads Hartvig} and Nielsen, {Thomas Eiland}",

note = "This article is published Open Access as part of the RSC's Gold for Gold initiative, licensed under a Creative Commons Attribution 3.0 Unported Licence.",

year = "2016",

doi = "10.1039/c6ob00961a",

language = "English",

volume = "14",

pages = "4943--4946",

journal = "Organic & Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "21",

}

TY - JOUR

T1 - Synthesis of sp3-rich scaffolds for molecular libraries through complexity-generating cascade reactions

AU - Flagstad, Thomas

AU - Min, Geanna

AU - Bonnet, K.

AU - Morgentin, R.

AU - Roche, D.

AU - Clausen, Mads Hartvig

AU - Nielsen, Thomas Eiland

N1 - This article is published Open Access as part of the RSC's Gold for Gold initiative, licensed under a Creative Commons Attribution 3.0 Unported Licence.

PY - 2016

Y1 - 2016

N2 - An efficient strategy for the synthesis of complex small molecules from simple building blocks is presented. Key steps of the strategy include tandem Petasis and Diels–Alder reactions, and divergent complexity-generating cyclization cascades from a key dialdehyde intermediate. The methodology is validated through the synthesis of a representative compound set, which has been used in the production of 1617 molecules for the European Lead Factory.

AB - An efficient strategy for the synthesis of complex small molecules from simple building blocks is presented. Key steps of the strategy include tandem Petasis and Diels–Alder reactions, and divergent complexity-generating cyclization cascades from a key dialdehyde intermediate. The methodology is validated through the synthesis of a representative compound set, which has been used in the production of 1617 molecules for the European Lead Factory.

U2 - 10.1039/c6ob00961a

DO - 10.1039/c6ob00961a

M3 - Journal article

C2 - 27171614

SN - 1477-0520

VL - 14

SP - 4943

EP - 4946

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 21

ER -

Synthesis of sp3-rich scaffolds for molecular libraries through complexity-generating cascade reactions

Abstract

Bibliographical note

Access to Document

OpenUrl availability

Fingerprint

Cite this