Synthesis of on-chip control circuits for mVLSI biochips

Seetal Potluri, Alexander Rüdiger Schneider, Martin Hørslev-Petersen, Paul Pop, Jan Madsen

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review


Microfluidic VLSI (mVLSI) biochips help perform biochemistry at miniaturized scales, thus enabling cost, performance and other benefits. Although biochips are expected to replace biochemical labs, including point-of-care devices, the off-chip pressure actuators and pumps are bulky, thereby limiting them to laboratory environments. To address this issue, researchers have proposed methods to reduce the number of offchip pressure sources, through integration of on-chip pneumatic control logic circuits fabricated using three-layer monolithic membrane valve technology. Traditionally, mVLSI biochip physical design was performed assuming that all of the control logic is off-chip. However, the problem of mVLSI biochip physical design changes significantly, with introduction of on-chip control, since along with physical synthesis, we also need to (i) perform on/off-chip control partitioning, (ii) on-chip control circuit design and (iii) the integration of on-chip control in the placement and routing design tasks. In this paper we present a design methodology for logic synthesis and physical synthesis of mVLSI biochips that use on-chip control. We show how the proposed methodology can be successfully applied to generate biochip layouts with integrated on-chip pneumatic control.
Original languageEnglish
Title of host publicationProceedings of 20th Design, Automation and Test in Europe
Publication date2017
Article number7927284
ISBN (Print)9783981537093
Publication statusPublished - 2017
Event20th Design, Automation and Test in Europe - SwissTech Convention Center, Lausanne, Switzerland
Duration: 27 Mar 201731 Mar 2017
Conference number: 20


Conference20th Design, Automation and Test in Europe
LocationSwissTech Convention Center
SeriesProceedings of the Design, Automation, and Test in Europe Conference and Exhibition


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