Synthesis of new 3-and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers

Jacob Alsbæk Olsen, Rune Eg Severinsen, Thomas Bovbjerg Rasmussen, Morten Hentzer, Michael Christian Givskov, John Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The quorum sensing mechanism in Gram-negative bacteria uses small intercellular signal molecules, N-acyl-homoserine lactones (AHLs), to control transcription of specific genes in relation to population density. In this communication, we describe the parallel synthesis of new AHL analogues, in which substituents have been introduced into the 3- and 4-positions of the lactone ring. These analogues have been screened for their ability to activate and inhibit a Vibrio fischeri LuxI/LuxR-derived quorum sensing reporter system.
Original languageEnglish
JournalBioorganic & medicinal chemistry letters
Volume12
Issue number3
Pages (from-to)325-328
ISSN0960-894X
Publication statusPublished - 2002

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