Synthesis of graphene quantum dots and their applications in drug delivery

Changhong Zhao; Xuebin Song; Ya Liu; Yifeng Fu; Lilei Ye; Nan Wang; Fan Wang; Lu Li; Mohsen Mohammadniaei; Ming Zhang; Qiqing Zhang; Johan Liu

doi:10.1186/s12951-020-00698-z

Synthesis of graphene quantum dots and their applications in drug delivery

Changhong Zhao^*
, Xuebin Song
, Ya Liu
, Yifeng Fu
, Lilei Ye
, Nan Wang
, Fan Wang
, Lu Li
, Mohsen Mohammadniaei
, Ming Zhang
, Qiqing Zhang
, Johan Liu

^*Corresponding author for this work

Shanghai University
Xinxiang Medical College
Chalmers University of Technology
SHT Smart High Tech AB

Research output: Contribution to journal › Review › peer-review

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Abstract

This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.[Figure not available: see fulltext.]

Original language	English
Article number	142
Journal	Journal of Nanobiotechnology
Volume	18
Issue number	1
Number of pages	32
ISSN	1477-3155
DOIs	https://doi.org/10.1186/s12951-020-00698-z
Publication status	Published - 2020

Keywords

Graphene quantum dots
Top-down
Bottom-up
Drug delivery
Delivery-release mode

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10.1186/s12951-020-00698-z

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title = "Synthesis of graphene quantum dots and their applications in drug delivery",

abstract = "This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.[Figure not available: see fulltext.]",

keywords = "Graphene quantum dots, Top-down, Bottom-up, Drug delivery, Delivery-release mode",

author = "Changhong Zhao and Xuebin Song and Ya Liu and Yifeng Fu and Lilei Ye and Nan Wang and Fan Wang and Lu Li and Mohsen Mohammadniaei and Ming Zhang and Qiqing Zhang and Johan Liu",

year = "2020",

doi = "10.1186/s12951-020-00698-z",

language = "English",

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TY - JOUR

T1 - Synthesis of graphene quantum dots and their applications in drug delivery

AU - Zhao, Changhong

AU - Song, Xuebin

AU - Liu, Ya

AU - Fu, Yifeng

AU - Ye, Lilei

AU - Wang, Nan

AU - Wang, Fan

AU - Li, Lu

AU - Mohammadniaei, Mohsen

AU - Zhang, Ming

AU - Zhang, Qiqing

AU - Liu, Johan

PY - 2020

Y1 - 2020

N2 - This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.[Figure not available: see fulltext.]

AB - This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.[Figure not available: see fulltext.]

KW - Graphene quantum dots

KW - Top-down

KW - Bottom-up

KW - Drug delivery

KW - Delivery-release mode

U2 - 10.1186/s12951-020-00698-z

DO - 10.1186/s12951-020-00698-z

M3 - Review

C2 - 33008457

SN - 1477-3155

VL - 18

JO - Journal of Nanobiotechnology

JF - Journal of Nanobiotechnology

IS - 1

M1 - 142

ER -

Synthesis of graphene quantum dots and their applications in drug delivery

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