Synthesis of graphene quantum dots and their applications in drug delivery

Changhong Zhao; Xuebin Song; Ya Liu; Yifeng Fu; Lilei Ye; Nan Wang; Fan Wang; Lu Li; Mohsen Mohammadniaei; Ming Zhang; Qiqing Zhang; Johan Liu

doi:10.1186/s12951-020-00698-z

Synthesis of graphene quantum dots and their applications in drug delivery

Changhong Zhao^*, Xuebin Song, Ya Liu, Yifeng Fu, Lilei Ye, Nan Wang, Fan Wang, Lu Li, Mohsen Mohammadniaei, Ming Zhang, Qiqing Zhang, Johan Liu

^*Corresponding author for this work

Research output: Contribution to journal › Review › peer-review

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Abstract

This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.[Figure not available: see fulltext.]

Original language	English
Article number	142
Journal	Journal of Nanobiotechnology
Volume	18
Issue number	1
Number of pages	32
ISSN	1477-3155
DOIs	https://doi.org/10.1186/s12951-020-00698-z
Publication status	Published - 2020

Keywords

Graphene quantum dots
Top-down
Bottom-up
Drug delivery
Delivery-release mode

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title = "Synthesis of graphene quantum dots and their applications in drug delivery",

abstract = "This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.[Figure not available: see fulltext.]",

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T1 - Synthesis of graphene quantum dots and their applications in drug delivery

AU - Zhao, Changhong

AU - Song, Xuebin

AU - Liu, Ya

AU - Fu, Yifeng

AU - Ye, Lilei

AU - Wang, Nan

AU - Wang, Fan

AU - Li, Lu

AU - Mohammadniaei, Mohsen

AU - Zhang, Ming

AU - Zhang, Qiqing

AU - Liu, Johan

PY - 2020

Y1 - 2020

N2 - This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.[Figure not available: see fulltext.]

AB - This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.[Figure not available: see fulltext.]

KW - Graphene quantum dots

KW - Top-down

KW - Bottom-up

KW - Drug delivery

KW - Delivery-release mode

U2 - 10.1186/s12951-020-00698-z

DO - 10.1186/s12951-020-00698-z

M3 - Review

C2 - 33008457

SN - 1477-3155

VL - 18

JO - Journal of Nanobiotechnology

JF - Journal of Nanobiotechnology

IS - 1

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ER -

Synthesis of graphene quantum dots and their applications in drug delivery

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