Abstract
The synthesis of 5- and 3-(1'-hydroxyalkyl)-substituted 5H-furan-2-ones 4a-d and 8a-d as well as 5-alkylidene-5H-furan-2-ones 5a-d is described. A study of the structure-activity relationship of these furanone-based natural product analogues towards two different quorum sensing systems is reported. Although the synthesized compounds are not as potent quorum sensing inhibitors as some natural counterparts and a synthetic analogue hereof, interesting structure-activity relationships are seen.
| Original language | English |
|---|---|
| Journal | Bioorganic & medicinal chemistry |
| Volume | 11 |
| Issue number | 15 |
| Pages (from-to) | 3261-3271 |
| ISSN | 0968-0896 |
| Publication status | Published - 2003 |