Synthesis of Cross-Linked Polymeric Micelle pH Nanosensors: An Investigation of Design Flexibility

Pramod Kumar Ek, Rasmus Irming Jølck, Thomas Lars Andresen

    Research output: Contribution to journalJournal articleResearchpeer-review


    The design flexibility that polymeric micelles offer in the fabrication of optical nanosensors for ratiometric pH measurements is investigated. pH nanosensors based on polymeric micelles are synthesized either by a mixed-micellization approach or by a postmicelle modification strategy. In the mixed-micellization approach, self-assembly of functionalized unimers followed by shell cross-linking by copper-catalyzed azide-alkyne cycloaddition (CuAAC) results in stabilized cRGD-functionalized micelle pH nanosensors. In the postmicelle modification strategy, simultaneous cross-linking and fluorophore conjugation at the micelle shell using CuAAC results in a stabilized micelle pH nanosensor. Compared to the postmicelle modification strategy, the mixed-micellization approach increases the control of the overall composition of the nanosensors.Both approaches provide stable nanosensors with similar pKa profiles and thereby nanosensors with similar pH sensitivity.
    Original languageEnglish
    JournalMacromolecular Rapid Communications
    Issue number17
    Pages (from-to)1598-1604
    Publication statusPublished - 2015


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