Synthesis of Constrained Peptidomimetics via the Pictet-Spengler Reaction

Rico Petersen, Vitaly V. Komnatnyy, Thomas E. Nielsen

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

Peptidomimetics offers a solution to the poor pharmacokinetic properties displayed by natural peptides, by providing pharmaceutically useful chemical structures with the ability to mimic the endogenous polyamide structure. This chapter gives an overview of the past decade’s developments in the field of Pictet-Spengler reactions for the synthesis of peptidomimetics, with an emphasis on the applications of constrained heterocycles in mimicry of peptide geometry and biology.
Original languageEnglish
Title of host publicationPeptidomimetics II
EditorsWilliam Lubell
Volume49
PublisherSpringer
Publication date2016
Pages81-103
ISBN (Print)978-3-319-49123-3
ISBN (Electronic)978-3-319-49124-0
DOIs
Publication statusPublished - 2016
SeriesTopics in Heterocyclic Chemistry
ISSN1861-9282

Keywords

  • Drug discovery
  • Peptidomimetics
  • Pictet-Spengler reaction

Cite this

Petersen, R., Komnatnyy, V. V., & Nielsen, T. E. (2016). Synthesis of Constrained Peptidomimetics via the Pictet-Spengler Reaction. In W. Lubell (Ed.), Peptidomimetics II (Vol. 49, pp. 81-103). Springer. Topics in Heterocyclic Chemistry https://doi.org/10.1007/7081_2015_190