Synthesis of antirrhinolide, a new lactone from Antirrhinum majus

Henrik Franzyk, Signe Maria Frederiksen, Søren Rosendal Jensen

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    In addition to the known iridoid glucosides antirrhinoside (1), antirrhide (3), antirrhinoside (1), linarioside (5) and chaenorrhinoside (6), a novel nonglucosidic iridoid lactone was isolated in trace amount from Antirrhinum majus (Scrophulariaceae). This lactone, named antirrhinolide (4a) was synthesised from 5,6-O-isopropylidene-dihydroantirrhinoside aglucone (7) in two steps. Thus, its absolute stereochemistry was proven unequivocally.
    Original languageEnglish
    JournalEuropean Journal of Organic Chemistry
    Pages (from-to)1665-1667
    Publication statusPublished - 1998

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