Four aminocyclopentanols, as mimics of putative intermediates in hydrolysis of a-D-galactosides, have been synthesized through a number of stereoselective transformations, using the cis-fused cyclopentane-1,4-lactone (1R, 5S, 7R, 8R)-7,8-dihydroxy-2-oxabicyclo[3.3.0]oct-3-one 1 as a chiral building block. The compounds were tested towards various glycosidases but showed no anomer selectivity in the inhibition of ą and ß galactosidases.
|Journal||Org. Biomol. Chem.|
|Publication status||Published - 2005|