Synthesis of aminocyclopentanols: a-D-galacto configured sugar mimics

Marie Bøjstrup, Inge Lundt

Research output: Contribution to journalJournal articleResearchpeer-review


Four aminocyclopentanols, as mimics of putative intermediates in hydrolysis of a-D-galactosides, have been synthesized through a number of stereoselective transformations, using the cis-fused cyclopentane-1,4-lactone (1R, 5S, 7R, 8R)-7,8-dihydroxy-2-oxabicyclo[3.3.0]oct-3-one 1 as a chiral building block. The compounds were tested towards various glycosidases but showed no anomer selectivity in the inhibition of ą and ß galactosidases.
Original languageEnglish
JournalOrg. Biomol. Chem.
Pages (from-to)1738-1745
Publication statusPublished - 2005


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