Synthesis of 1,4,5 trisubstituted γ-lactams via a 3-component cascade reaction

Michael Åxman Petersen, Michael Agerup Mortensen, A. Emil Cohrt, Rico Petersen, Peng Wu, Nicolas Fleury-Brégeot, Rémy Morgentin, Claude Lardy, Thomas Eiland Nielsen, Mads Hartvig Clausen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A three component one-pot cascade reaction was developed for the synthesis of 1,4,5-trisubstituted γ-lactams. The resulting scaffold can be modified independently at three positions, two of which are conveniently accessed by changing the components of the one-pot reaction. The phases of building block generation, scaffold synthesis and subsequent appendage modification were adapted to library production, which resulted in a screening library of 500 compounds.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry
Volume23
Issue number11
Pages (from-to)2695-2698
Number of pages4
ISSN0968-0896
DOIs
Publication statusPublished - 2015

Keywords

  • γ-Lactams
  • Cascade reaction
  • One-pot reaction
  • Molecular diversity
  • Library production

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