Synthesis and single crystal X-ray analysis of two griseofulvin metabolites

Mads Holger Rønnest; Pernille Harris; Charlotte Held Gotfredsen; T.O. Larsen; Mads Hartvig Clausen

doi:10.1016/j.tetlet.2010.08.095

Synthesis and single crystal X-ray analysis of two griseofulvin metabolites

Mads Holger Rønnest
, Pernille Harris
, Charlotte Held Gotfredsen
, T.O. Larsen
, Mads Hartvig Clausen

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The two phenols, 6-O-desmethyl griseofulvin and 4-O-desmethyl griseofulvin are metabolites of the antifungal drug griseofulvin. Herein, we present an improved synthesis of the 6-phenol derivative, and an unequivocal proof of both structures by single-crystal X-ray analysis.

Original language	English
Journal	Tetrahedron Letters
Volume	51
Issue number	45
Pages (from-to)	5881-5882
ISSN	0040-4039
DOIs	https://doi.org/10.1016/j.tetlet.2010.08.095
Publication status	Published - 2010

Keywords

Griseofulvin
Metabolites
Synthesis
X-ray structures

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10.1016/j.tetlet.2010.08.095

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title = "Synthesis and single crystal X-ray analysis of two griseofulvin metabolites",

abstract = "The two phenols, 6-O-desmethyl griseofulvin and 4-O-desmethyl griseofulvin are metabolites of the antifungal drug griseofulvin. Herein, we present an improved synthesis of the 6-phenol derivative, and an unequivocal proof of both structures by single-crystal X-ray analysis.",

keywords = "Griseofulvin, Metabolites, Synthesis, X-ray structures",

author = "R{\o}nnest, \{Mads Holger\} and Pernille Harris and Gotfredsen, \{Charlotte Held\} and T.O. Larsen and Clausen, \{Mads Hartvig\}",

year = "2010",

doi = "10.1016/j.tetlet.2010.08.095",

language = "English",

volume = "51",

pages = "5881--5882",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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TY - JOUR

T1 - Synthesis and single crystal X-ray analysis of two griseofulvin metabolites

AU - Rønnest, Mads Holger

AU - Harris, Pernille

AU - Gotfredsen, Charlotte Held

AU - Larsen, T.O.

AU - Clausen, Mads Hartvig

PY - 2010

Y1 - 2010

N2 - The two phenols, 6-O-desmethyl griseofulvin and 4-O-desmethyl griseofulvin are metabolites of the antifungal drug griseofulvin. Herein, we present an improved synthesis of the 6-phenol derivative, and an unequivocal proof of both structures by single-crystal X-ray analysis.

AB - The two phenols, 6-O-desmethyl griseofulvin and 4-O-desmethyl griseofulvin are metabolites of the antifungal drug griseofulvin. Herein, we present an improved synthesis of the 6-phenol derivative, and an unequivocal proof of both structures by single-crystal X-ray analysis.

KW - Griseofulvin

KW - Metabolites

KW - Synthesis

KW - X-ray structures

U2 - 10.1016/j.tetlet.2010.08.095

DO - 10.1016/j.tetlet.2010.08.095

M3 - Journal article

SN - 0040-4039

VL - 51

SP - 5881

EP - 5882

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 45

ER -

Synthesis and single crystal X-ray analysis of two griseofulvin metabolites

Abstract

Keywords

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