The two phenols, 6-O-desmethyl griseofulvin and 4-O-desmethyl griseofulvin are metabolites of the antifungal drug griseofulvin. Herein, we present an improved synthesis of the 6-phenol derivative, and an unequivocal proof of both structures by single-crystal X-ray analysis.
- X-ray structures
Rønnest, M. H., Harris, P., Gotfredsen, C. H., Larsen, T. O., & Clausen, M. H. (2010). Synthesis and single crystal X-ray analysis of two griseofulvin metabolites. Tetrahedron Letters, 51(45), 5881-5882. https://doi.org/10.1016/j.tetlet.2010.08.095