Synthesis and single crystal X-ray analysis of two griseofulvin metabolites

Mads Holger Rønnest, Pernille Harris, Charlotte Held Gotfredsen, T.O. Larsen, Mads Hartvig Clausen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The two phenols, 6-O-desmethyl griseofulvin and 4-O-desmethyl griseofulvin are metabolites of the antifungal drug griseofulvin. Herein, we present an improved synthesis of the 6-phenol derivative, and an unequivocal proof of both structures by single-crystal X-ray analysis.
Original languageEnglish
JournalTetrahedron Letters
Volume51
Issue number45
Pages (from-to)5881-5882
ISSN0040-4039
DOIs
Publication statusPublished - 2010

Keywords

  • Griseofulvin
  • Metabolites
  • Synthesis
  • X-ray structures

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