Synthesis and Evaluation of Desmethyl Azumamide Analogs

Pharmacology, Toxicology and Pharmaceutical Science

• Histone Deacetylase 100%
• Natural Product 40%
• Methyl Group 30%
• Amino Acid 20%
• Structure Activity Relationship 10%
• Clinical Trial 10%
• Receptor 10%
• Binding Site 10%
• Isoenzyme 10%
• Lysine 10%
• Malignant Neoplasm 10%
• Anticarcinogen 10%
• Thiol 10%
• Prodrug 10%
• Thioester 10%
• Cyclopeptide 10%
• Thiol Group 10%
• Ligand Gated Ion Channel 10%
• Histone Deacetylase 3 10%
• Histone 10%

Chemistry

• Histone 100%
• Occurrence in Nature 36%
• Methyl Group 27%
• Amino Acid 18%
• Prodrug 9%
• Binding Site 9%
• Lysine Residue 9%
• Cyclic Peptide 9%
• Thioester 9%
• Thiol Group 9%
• Antineoplastic Agent 9%
• NMR Spectroscopy 9%
• Acylation 9%
• Thiol 9%
• Structure-Activity Relationship 9%

Keyphrases

• Largazole 33%
• Cell-penetrating Property 16%
• Cap Group 16%
• CASPER 16%
• Epigenetic Modulators 16%