Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution

Paolo Marizza, M. Abrami, Stephan Sylvest Keller, P. Posocco, E. Laurini, Kaustav Goswami, Anne Ladegaard Skov, Anja Boisen, D. Larobina, G. Grassi, M. Grassi

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Abstract

Hydrogels of poly(n-vinyl-2-pyrrolidone) were produced by UV irradiation of aqueous solutions of the polymer in presence of hydrogen peroxide, used as initiator. The mechanical and the nanostructural properties of the gels were characterized by a combination of experimental techniques including rheology, low field nuclear magnetic resonance spectroscopy (LF-NMR), and small angle X-ray scattering. Different irradiation doses as well as polymer and initiator concentrations were tested in the characterization. The study elucidates the relationship between different methods to estimate the mesh size of the gel polymeric network. Moreover, a novel correlation model was developed based on Chui and Scherer theories for the interpretation of LF-NMR dataset of polymer solutions and networks.
Original languageEnglish
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume65
Issue number10
Pages (from-to)516-525
ISSN0091-4037
DOIs
Publication statusPublished - 2016

Keywords

  • Hydrogels
  • Drug delivery
  • Photocrosslinking
  • Polymer network morphology
  • Rheology
  • Modeling

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