Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution

Paolo Marizza; M. Abrami; Stephan Sylvest Keller; P. Posocco; E. Laurini; Kaustav Goswami; Anne Ladegaard Skov; Anja Boisen; D. Larobina; G. Grassi; M. Grassi

doi:10.1080/00914037.2015.1129964

Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution

Paolo Marizza, M. Abrami, Stephan Sylvest Keller, P. Posocco, E. Laurini, Kaustav Goswami, Anne Ladegaard Skov, Anja Boisen, D. Larobina, G. Grassi, M. Grassi

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Hydrogels of poly(n-vinyl-2-pyrrolidone) were produced by UV irradiation of aqueous solutions of the polymer in presence of hydrogen peroxide, used as initiator. The mechanical and the nanostructural properties of the gels were characterized by a combination of experimental techniques including rheology, low field nuclear magnetic resonance spectroscopy (LF-NMR), and small angle X-ray scattering. Different irradiation doses as well as polymer and initiator concentrations were tested in the characterization. The study elucidates the relationship between different methods to estimate the mesh size of the gel polymeric network. Moreover, a novel correlation model was developed based on Chui and Scherer theories for the interpretation of LF-NMR dataset of polymer solutions and networks.

Original language	English
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	65
Issue number	10
Pages (from-to)	516-525
ISSN	0091-4037
DOIs	https://doi.org/10.1080/00914037.2015.1129964
Publication status	Published - 2016

Keywords

Hydrogels
Drug delivery
Photocrosslinking
Polymer network morphology
Rheology
Modeling

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Characterization of poly n vinyl 2 pyrrolidone gels for the realization of micro drug delivery systemsAccepted author manuscript, 252 KB

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Marizza, P., Abrami, M., Keller, S. S., Posocco, P., Laurini, E., Goswami, K., Skov, A. L., Boisen, A., Larobina, D., Grassi, G., & Grassi, M. (2016). Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution. International Journal of Polymeric Materials and Polymeric Biomaterials, 65(10), 516-525. https://doi.org/10.1080/00914037.2015.1129964

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title = "Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution",

abstract = "Hydrogels of poly(n-vinyl-2-pyrrolidone) were produced by UV irradiation of aqueous solutions of the polymer in presence of hydrogen peroxide, used as initiator. The mechanical and the nanostructural properties of the gels were characterized by a combination of experimental techniques including rheology, low field nuclear magnetic resonance spectroscopy (LF-NMR), and small angle X-ray scattering. Different irradiation doses as well as polymer and initiator concentrations were tested in the characterization. The study elucidates the relationship between different methods to estimate the mesh size of the gel polymeric network. Moreover, a novel correlation model was developed based on Chui and Scherer theories for the interpretation of LF-NMR dataset of polymer solutions and networks.",

keywords = "Hydrogels, Drug delivery, Photocrosslinking, Polymer network morphology, Rheology, Modeling",

author = "Paolo Marizza and M. Abrami and Keller, {Stephan Sylvest} and P. Posocco and E. Laurini and Kaustav Goswami and Skov, {Anne Ladegaard} and Anja Boisen and D. Larobina and G. Grassi and M. Grassi",

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language = "English",

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pages = "516--525",

journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",

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Marizza, P, Abrami, M, Keller, SS, Posocco, P, Laurini, E, Goswami, K, Skov, AL , Boisen, A, Larobina, D, Grassi, G & Grassi, M 2016, 'Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution', International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 65, no. 10, pp. 516-525. https://doi.org/10.1080/00914037.2015.1129964

Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution. / Marizza, Paolo; Abrami, M.; Keller, Stephan Sylvest et al.
In: International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 65, No. 10, 2016, p. 516-525.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution

AU - Marizza, Paolo

AU - Abrami, M.

AU - Keller, Stephan Sylvest

AU - Posocco, P.

AU - Laurini, E.

AU - Goswami, Kaustav

AU - Skov, Anne Ladegaard

AU - Boisen, Anja

AU - Larobina, D.

AU - Grassi, G.

AU - Grassi, M.

PY - 2016

Y1 - 2016

N2 - Hydrogels of poly(n-vinyl-2-pyrrolidone) were produced by UV irradiation of aqueous solutions of the polymer in presence of hydrogen peroxide, used as initiator. The mechanical and the nanostructural properties of the gels were characterized by a combination of experimental techniques including rheology, low field nuclear magnetic resonance spectroscopy (LF-NMR), and small angle X-ray scattering. Different irradiation doses as well as polymer and initiator concentrations were tested in the characterization. The study elucidates the relationship between different methods to estimate the mesh size of the gel polymeric network. Moreover, a novel correlation model was developed based on Chui and Scherer theories for the interpretation of LF-NMR dataset of polymer solutions and networks.

AB - Hydrogels of poly(n-vinyl-2-pyrrolidone) were produced by UV irradiation of aqueous solutions of the polymer in presence of hydrogen peroxide, used as initiator. The mechanical and the nanostructural properties of the gels were characterized by a combination of experimental techniques including rheology, low field nuclear magnetic resonance spectroscopy (LF-NMR), and small angle X-ray scattering. Different irradiation doses as well as polymer and initiator concentrations were tested in the characterization. The study elucidates the relationship between different methods to estimate the mesh size of the gel polymeric network. Moreover, a novel correlation model was developed based on Chui and Scherer theories for the interpretation of LF-NMR dataset of polymer solutions and networks.

KW - Hydrogels

KW - Drug delivery

KW - Photocrosslinking

KW - Polymer network morphology

KW - Rheology

KW - Modeling

U2 - 10.1080/00914037.2015.1129964

DO - 10.1080/00914037.2015.1129964

M3 - Journal article

SN - 0091-4037

VL - 65

SP - 516

EP - 525

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

IS - 10

ER -

Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution

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