Synthesis and characterization of strontium carboxylates at room temperature and at high temperature in autoclave vessels

Stephan Christgau, Kenny Ståhl, Jens Enevold Thaulov Andersen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    A novel method was developed for synthesis of strontium coordination compounds in high yields. The synthesis proceeded along three pathways that provided strontium salts in high purity and high yields, close to 100%, as confirmed by flame atomic absorption spectroscopy (FAAS) and powder x-ray crystallography. Optimum conditions were found at T = 120-1400C, a base-to-acid ratio of 1.2 and 15 min. of reaction-time in an autoclave vessel. Large crystals were readily obtained within a time period of hours. The crystal structures of strontium D-glutamate hexahydrate (I) and strontium di-(hydrogen L-glutamate) pentahydrate (II) were confirmed by X-ray powder diffraction at 295 K and Rietveld refinements (I: Space group P212121, Z=4, a=7.3519(2), b=8.7616(2), c=20.2627(5) Å, and II: Space group P21, Z=2, a=8.7243(1), b=7.2635(1), c=14.6840(2) Å, β=100.5414(7) °). Synthesis at room temperature provided four additional new strontium compounds that may be applicable as constituents of pharmaceutical products for the treatment of bone conditions.
    Original languageEnglish
    JournalJournal of Coordination Chemistry
    Volume59
    Issue number18
    Pages (from-to)2023-2030
    ISSN0095-8972
    DOIs
    Publication statusPublished - 2006

    Keywords

    • Anions
    • Amino acids
    • Strontium
    • Caboxylates
    • X-ray diffraction

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