Synthesis and characterization of covalent diphenylalanine nanotube-folic acid conjugates

John Jairo Castillo León, Tomas Rindzevicius, Kaiyu Wu, Michael Stenbæk Schmidt, Katarzyna Agnieszka Janik, Anja Boisen, Winnie Edith Svendsen, Noemi Rozlosnik, Jaime Castillo

    Research output: Contribution to journalJournal articleResearchpeer-review

    1 Downloads (Pure)


    Herein, we describe the synthesis and characterization of a covalent nanoscale assembly formed between diphenylalanine micro/nanotubes (PNT) and folic acid (FA). The conjugate was obtained via chemical functionalization through coupling of amine groups of PNTs and carboxylic groups of FA. The surface analysis of PNT-FA indicated the presence of FA aggregates on the surface of PNTs. The
    covalent interaction between FA and self-assembled PNTs was further investigated using fluorescence microscopy, Raman and surface-enhanced Raman scattering (SERS) spectroscopies. The SERS experiments were performed on a large area silver-capped (diameter of 62 nm) silicon nanopillars with an approximate height of 400 nm and a width of 200 nm. The results showed that the PNT-FA synthesis procedure preserves the molecular structure of FA. The PNT-FA conjugate presented in this study is a promising candidate for applications in the detection and diagnosis of cancer or tropical diseases such as leishmaniasis and as a carrier nanosystem delivering drugs to malignant tumors that overexpress folate receptors.
    Original languageEnglish
    Article number2525
    JournalJournal of Nanoparticle Research
    Issue number7
    Number of pages8
    Publication statusPublished - 2014


    Dive into the research topics of 'Synthesis and characterization of covalent diphenylalanine nanotube-folic acid conjugates'. Together they form a unique fingerprint.

    Cite this