Synergistic combinations of antifungals and antivirulence agents to fight against Candida albicans

Jinhui Cui, Biao Ren, Yaojun Tong, Huanqin Dai, Lixin Zhang

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Candida albicans, one of the pathogenic Candida species, causes high mortality rate in immunocompromised and high-risk surgical patients. In the last decade, only one new class of antifungal drug echinocandin was applied. The increased therapy failures, such as the one caused by multi-drug resistance, demand innovative strategies for new effective antifungal drugs. Synergistic combinations of antifungals and anti-virulence agents highlight the pragmatic strategy to reduce the development of drug resistant and potentially repurpose known antifungals, which bypass the costly and time-consuming pipeline of new drug development. Anti-virulence and synergistic combination provide new options for antifungal drug discovery by counteracting the difficulty or failure of traditional therapy for fungal infections.
Original languageEnglish
JournalVirulence
Volume6
Issue number4
Pages (from-to)362-371
Number of pages10
ISSN2150-5594
DOIs
Publication statusPublished - 2015

Keywords

  • Candida albicans
  • Virulence factors
  • Drug resistance
  • Antifungal drug
  • Synergy

Fingerprint Dive into the research topics of 'Synergistic combinations of antifungals and antivirulence agents to fight against Candida albicans'. Together they form a unique fingerprint.

Cite this