Synchronization Phenomena in Nephron-Nephron Interaction

N.-H. Holstein-Rathlou, K.-P. Yip, Olga Sosnovtseva, Erik Mosekilde

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Abstract

Experimental data for tubular pressure oscillations in rat kidneys are analyzed in order to examine the different types of synchronization that can arise between neighboring functional units. For rats with normal blood pressure, the individual unit (the nephron) typically exhibits regular oscillations in its tubular pressure and flow variations. For such rats, both in-phase and antiphase synchronization can be demonstrated in the experimental data. For spontaneously hypertensive rats, where the pressure variations in the individual nephrons are highly irregular, signs of chaotic phase and frequency synchronization can be observed. Accounting for a hemodynamic as well as for a vascular coupling between nephrons that share a common interlobular artery, we develop a mathematical model of the pressure and flow regulation in a pair of adjacent nephrons. We show that this model, for appropriate values of the parameters, can reproduce the different types of experimentally observed synchronization. ©2001 American Institute of Physics.
Original languageEnglish
JournalChaos
Volume11
Issue number2
Pages (from-to)417-426
ISSN1054-1500
DOIs
Publication statusPublished - 2001

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Copyright (2001) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

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