Surfactin Facilitates Horizontal Gene Transfer in Bacillus subtilis

Tjasa Danevcic*, Anna Dragos, Mihael Spacapan, Polonca Stefanic, Iztok Dogsa, Ines Mandic-Mulec

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

101 Downloads (Pure)


Genetic competence for the uptake and integration of extracellular DNA is a key process in horizontal gene transfer (HGT), one of the most powerful forces driving the evolution of bacteria. In several species, development of genetic competence is coupled with cell lysis. Using Bacillus subtilis as a model bacterium, we studied the role of surfactin, a powerful biosurfactant and antimicrobial lipopeptide, in genetic transformation. We showed that surfactin itself promotes cell lysis and DNA release, thereby promoting HGT. These results, therefore, provide evidence for a fundamental mechanism involved in HGT and significantly increase our understanding of the spreading of antibiotic resistance genes and diversification of microbial communities in the environment.
Original languageEnglish
Article number657407
JournalFrontiers in Microbiology
Number of pages8
Publication statusPublished - 2021


  • Quorum sensing
  • Competence
  • Surfactin
  • DNA exchange
  • Extracellular DNA
  • Cell lysis
  • Horizontal gene transfer


Dive into the research topics of 'Surfactin Facilitates Horizontal Gene Transfer in Bacillus subtilis'. Together they form a unique fingerprint.

Cite this