Surface modification of polysulfone membranes applied for a membrane reactor with immobilized alcohol dehydrogenase

Christian Hoffmann, Harald Silau, Manuel Pinelo, John M. Woodley, Anders E. Daugaard*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Commercially available polysulfone (PSf) membranes with a polypropylene backing are used across a broad range of applications. However, the natural properties of the PSf surface sometimes limit their application. Here we present, how the surface of supported membranes can be heterogeneously activated by lithiation followed by functionalization with acid chlorides at 0 °C, permitting modification of commercial PSf membranes without compromising the mechanical integrity of the membrane. Post-functionalization polymer grafting was illustrated through both, a “grafting from” approach by surface initiated atom transfer radical polymerization (SI-ATRP) and by a “grafting to” approach exploiting Cu(I) catalyzed 1,3-cycloadditions of alkynes with azides (CuAAC) introducing hydrophilic polymers onto the membrane surface. Poly(1-vinyl imidazole) (pVim) grafted membranes were exploited as support for immobilization of alcohol dehydrogenase (ADH) in a biocatalytic membrane reactor (BMR) and demonstrated substantial improvements in terms of operational enzyme stability compared to immobilization onto pristine membranes.
Original languageEnglish
JournalMaterials Today Communications
Volume14
Pages (from-to)160-168
ISSN2352-4928
DOIs
Publication statusPublished - 2018

Keywords

  • Materials Science (all)
  • Mechanics of Materials
  • Materials Chemistry
  • Enzyme immobilization
  • Polysulfone membrane
  • Surface functionalization

Cite this

@article{7211cb74a33748488e72c258c130d2e3,
title = "Surface modification of polysulfone membranes applied for a membrane reactor with immobilized alcohol dehydrogenase",
abstract = "Commercially available polysulfone (PSf) membranes with a polypropylene backing are used across a broad range of applications. However, the natural properties of the PSf surface sometimes limit their application. Here we present, how the surface of supported membranes can be heterogeneously activated by lithiation followed by functionalization with acid chlorides at 0 °C, permitting modification of commercial PSf membranes without compromising the mechanical integrity of the membrane. Post-functionalization polymer grafting was illustrated through both, a “grafting from” approach by surface initiated atom transfer radical polymerization (SI-ATRP) and by a “grafting to” approach exploiting Cu(I) catalyzed 1,3-cycloadditions of alkynes with azides (CuAAC) introducing hydrophilic polymers onto the membrane surface. Poly(1-vinyl imidazole) (pVim) grafted membranes were exploited as support for immobilization of alcohol dehydrogenase (ADH) in a biocatalytic membrane reactor (BMR) and demonstrated substantial improvements in terms of operational enzyme stability compared to immobilization onto pristine membranes.",
keywords = "Materials Science (all), Mechanics of Materials, Materials Chemistry, Enzyme immobilization, Polysulfone membrane, Surface functionalization",
author = "Christian Hoffmann and Harald Silau and Manuel Pinelo and Woodley, {John M.} and Daugaard, {Anders E.}",
year = "2018",
doi = "10.1016/j.mtcomm.2017.12.019",
language = "English",
volume = "14",
pages = "160--168",
journal = "Materials Today Communications",
issn = "2352-4928",
publisher = "Elsevier",

}

Surface modification of polysulfone membranes applied for a membrane reactor with immobilized alcohol dehydrogenase. / Hoffmann, Christian; Silau, Harald; Pinelo, Manuel; Woodley, John M.; Daugaard, Anders E.

In: Materials Today Communications, Vol. 14, 2018, p. 160-168.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Surface modification of polysulfone membranes applied for a membrane reactor with immobilized alcohol dehydrogenase

AU - Hoffmann, Christian

AU - Silau, Harald

AU - Pinelo, Manuel

AU - Woodley, John M.

AU - Daugaard, Anders E.

PY - 2018

Y1 - 2018

N2 - Commercially available polysulfone (PSf) membranes with a polypropylene backing are used across a broad range of applications. However, the natural properties of the PSf surface sometimes limit their application. Here we present, how the surface of supported membranes can be heterogeneously activated by lithiation followed by functionalization with acid chlorides at 0 °C, permitting modification of commercial PSf membranes without compromising the mechanical integrity of the membrane. Post-functionalization polymer grafting was illustrated through both, a “grafting from” approach by surface initiated atom transfer radical polymerization (SI-ATRP) and by a “grafting to” approach exploiting Cu(I) catalyzed 1,3-cycloadditions of alkynes with azides (CuAAC) introducing hydrophilic polymers onto the membrane surface. Poly(1-vinyl imidazole) (pVim) grafted membranes were exploited as support for immobilization of alcohol dehydrogenase (ADH) in a biocatalytic membrane reactor (BMR) and demonstrated substantial improvements in terms of operational enzyme stability compared to immobilization onto pristine membranes.

AB - Commercially available polysulfone (PSf) membranes with a polypropylene backing are used across a broad range of applications. However, the natural properties of the PSf surface sometimes limit their application. Here we present, how the surface of supported membranes can be heterogeneously activated by lithiation followed by functionalization with acid chlorides at 0 °C, permitting modification of commercial PSf membranes without compromising the mechanical integrity of the membrane. Post-functionalization polymer grafting was illustrated through both, a “grafting from” approach by surface initiated atom transfer radical polymerization (SI-ATRP) and by a “grafting to” approach exploiting Cu(I) catalyzed 1,3-cycloadditions of alkynes with azides (CuAAC) introducing hydrophilic polymers onto the membrane surface. Poly(1-vinyl imidazole) (pVim) grafted membranes were exploited as support for immobilization of alcohol dehydrogenase (ADH) in a biocatalytic membrane reactor (BMR) and demonstrated substantial improvements in terms of operational enzyme stability compared to immobilization onto pristine membranes.

KW - Materials Science (all)

KW - Mechanics of Materials

KW - Materials Chemistry

KW - Enzyme immobilization

KW - Polysulfone membrane

KW - Surface functionalization

U2 - 10.1016/j.mtcomm.2017.12.019

DO - 10.1016/j.mtcomm.2017.12.019

M3 - Journal article

VL - 14

SP - 160

EP - 168

JO - Materials Today Communications

JF - Materials Today Communications

SN - 2352-4928

ER -