Surface Modification of Photoresist SU-8 for Low Autofluorescence and Bioanalytical Applications

Cuong Cao, Sam W. Birtwell, Jonas Høgberg, Anders Wolff, Hywel Morgan, Dang Duong Bang

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    Abstract

    This paper reports a surface modification of epoxy-based negative photoresist SU-8 for reducing its autofluorescence while enhancing its biofunctionality. By covalently depositing a thin layer of 20 nm Au nanoparticles (AuNPs) onto the SU-8 surface, we found that the AuNPs-coated SU-8 surface is much less fluorescent than the untreated SU-8. Moreover, DNA probes can easily be immobilized on the Au surface and are thermally stable over a wide range of temperature. These improvements will benefit bioanalytical applications such as DNA hybridization and solid-phase PCR (SP-PCR).
    Original languageEnglish
    Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    PublisherChemical and Biological Microsystems Society
    Publication date2011
    Pages1161-1163
    ISBN (Print)978-0-9798064-4-5
    Publication statusPublished - 2011
    Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Seattle, WA, United States
    Duration: 2 Oct 20116 Oct 2011
    http://www.microtas2011.org/

    Conference

    Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    CountryUnited States
    CitySeattle, WA
    Period02/10/201106/10/2011
    Internet address

    Keywords

    • DNA Detection
    • SU-8
    • Gold Nanoparticles
    • Autofluorescence,
    • Photoresist

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