The emergence of 2D SERS substrates with large areas of hot spots has enabled data to be gathered at large scale. This work presents a statistical tool for analysing large amounts of SERS data by utilizing a peak-fitting model in a specific spectral range. By analysing the distributions of Raman intensities and peak positions it is possible to directly inspect the interplay between DNA and 6-mercapto-1-hexanol on gold covered nanopillars. It is demonstrated that optimised functionalization parameters can be extracted from the Raman spectra directly. Using the peak-fitting approach it is possible to avoid miss-interpretation of intensity histograms, where contamination might contribute with an enhanced background and not a peak.
- Area mapping
Frøhling, K. B., Alstrøm, T. S., Bache, M., Schmidt, M. S., Schmidt, M. N., Larsen, J., Jakobsen, M. H., & Boisen, A. (2016). Surface-enhanced Raman spectroscopic study of DNA and 6-mercapto-1-hexanol interactions using large area mapping. Vibrational Spectroscopy, 86, 331-336. https://doi.org/10.1016/j.vibspec.2016.08.005