Supramolecular chemical shift reagents inducing conformational transitions: NMR analysis of carbohydrate homooligomer mixtures

Sophie Beeren; Sebastian Meier

doi:10.1039/C4CC09710F

Supramolecular chemical shift reagents inducing conformational transitions: NMR analysis of carbohydrate homooligomer mixtures

Sophie Beeren, Sebastian Meier

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

We introduce the concept of supramolecular chemical shift reagents as a tool to improve signal resolution for the NMR analysis of homooligomers. Non-covalent interactions with the shift reagent can constrain otherwise flexible analytes inducing a conformational transition that results in signal separation. Here we use this approach for the quantitative analysis of a complex homooligomeric glycan mixture.

Original language	English
Journal	Chemical Communications
Volume	51
Pages (from-to)	3073-3076
Number of pages	4
ISSN	1359-7345
DOIs	https://doi.org/10.1039/C4CC09710F
Publication status	Published - 2015

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10.1039/C4CC09710F

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abstract = "We introduce the concept of supramolecular chemical shift reagents as a tool to improve signal resolution for the NMR analysis of homooligomers. Non-covalent interactions with the shift reagent can constrain otherwise flexible analytes inducing a conformational transition that results in signal separation. Here we use this approach for the quantitative analysis of a complex homooligomeric glycan mixture.",

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publisher = "Royal Society of Chemistry",

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AU - Meier, Sebastian

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AB - We introduce the concept of supramolecular chemical shift reagents as a tool to improve signal resolution for the NMR analysis of homooligomers. Non-covalent interactions with the shift reagent can constrain otherwise flexible analytes inducing a conformational transition that results in signal separation. Here we use this approach for the quantitative analysis of a complex homooligomeric glycan mixture.

U2 - 10.1039/C4CC09710F

DO - 10.1039/C4CC09710F

M3 - Journal article

VL - 51

SP - 3073

EP - 3076

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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