Supplementation With Fish Oil in Pregnancy Reduces Gastroenteritis in Early Childhood

David Horner; Mathis Hjort Hjelmso; Jonathan Thorsen; Morten Rasmussen; Anders Eliasen; Rebecca Kofod Vinding; Ann-Marie Malby Schoos; Nicklas Brustad; Rikke Bjersand Sunde; Klaus Bonnelykke; Bo L. Chawes; Jakob Stokholm; Hans Bisgaard

doi:10.1093/infdis/jiab607

Supplementation With Fish Oil in Pregnancy Reduces Gastroenteritis in Early Childhood

David Horner, Mathis Hjort Hjelmso, Jonathan Thorsen, Morten Rasmussen, Anders Eliasen, Rebecca Kofod Vinding, Ann-Marie Malby Schoos, Nicklas Brustad, Rikke Bjersand Sunde, Klaus Bonnelykke, Bo L. Chawes, Jakob Stokholm, Hans Bisgaard^*

^*Corresponding author for this work

University of Copenhagen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Background. We hypothesized that insufficient intake of fish oil-derived omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) during pregnancy is a contributing factor to gastroenteritis in early childhood. We examined the effect of n-3 LCPUFA supplementation on gastroenteritis symptoms in the offspring's first 3 years of life.
Methods. This was a double-blinded, randomized controlled trial whereby 736 mothers were administered n-3 LCPUFA or control from pregnancy week 24 until 1 week after birth. We measured the number of days with gastroenteritis, number of episodes with gastroenteritis, and the risk of having a gastroenteritis episode in the first 3 years of life.
Results. A median reduction of 2.5 days with gastroenteritis (P = .018) was shown, corresponding to a 14% reduction in the n-3 LCPUFA group compared with controls in the first 3 years of life (P = .037). A reduction in the number of gastroenteritis episodes (P = .027) and a reduced risk of having an episode (hazard ratio, 0.80 [95% confidence interval, .66-.97]; P = .023) were also shown.
Conclusions. Fish oil supplementation from the 24th week of pregnancy led to a reduction in the number of days and episodes with gastroenteritis symptoms in the first 3 years of life. The findings suggest n-3 LCPUFA supplementation as a preventive measure against gastrointestinal infections in early childhood.

Original language	English
Journal	Journal of Infectious Diseases
Volume	227
Issue number	3
Pages (from-to)	448–456
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jiab607
Publication status	Published - 2023

Keywords

Fish oil
Gastroenteritis
Pediatrics
Pregnancy supplementation

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Horner, D., Hjelmso, M. H., Thorsen, J., Rasmussen, M., Eliasen, A., Vinding, R. K., Schoos, A.-M. M., Brustad, N., Sunde, R. B., Bonnelykke, K., Chawes, B. L., Stokholm, J., & Bisgaard, H. (2023). Supplementation With Fish Oil in Pregnancy Reduces Gastroenteritis in Early Childhood. Journal of Infectious Diseases, 227(3), 448–456. https://doi.org/10.1093/infdis/jiab607

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title = "Supplementation With Fish Oil in Pregnancy Reduces Gastroenteritis in Early Childhood",

abstract = "Background. We hypothesized that insufficient intake of fish oil-derived omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) during pregnancy is a contributing factor to gastroenteritis in early childhood. We examined the effect of n-3 LCPUFA supplementation on gastroenteritis symptoms in the offspring's first 3 years of life. Methods. This was a double-blinded, randomized controlled trial whereby 736 mothers were administered n-3 LCPUFA or control from pregnancy week 24 until 1 week after birth. We measured the number of days with gastroenteritis, number of episodes with gastroenteritis, and the risk of having a gastroenteritis episode in the first 3 years of life. Results. A median reduction of 2.5 days with gastroenteritis (P = .018) was shown, corresponding to a 14% reduction in the n-3 LCPUFA group compared with controls in the first 3 years of life (P = .037). A reduction in the number of gastroenteritis episodes (P = .027) and a reduced risk of having an episode (hazard ratio, 0.80 [95% confidence interval, .66-.97]; P = .023) were also shown. Conclusions. Fish oil supplementation from the 24th week of pregnancy led to a reduction in the number of days and episodes with gastroenteritis symptoms in the first 3 years of life. The findings suggest n-3 LCPUFA supplementation as a preventive measure against gastrointestinal infections in early childhood.",

keywords = "Fish oil, Gastroenteritis, Pediatrics, Pregnancy supplementation",

author = "David Horner and Hjelmso, {Mathis Hjort} and Jonathan Thorsen and Morten Rasmussen and Anders Eliasen and Vinding, {Rebecca Kofod} and Schoos, {Ann-Marie Malby} and Nicklas Brustad and Sunde, {Rikke Bjersand} and Klaus Bonnelykke and Chawes, {Bo L.} and Jakob Stokholm and Hans Bisgaard",

year = "2023",

doi = "10.1093/infdis/jiab607",

language = "English",

volume = "227",

pages = "448–456",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

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T1 - Supplementation With Fish Oil in Pregnancy Reduces Gastroenteritis in Early Childhood

AU - Horner, David

AU - Hjelmso, Mathis Hjort

AU - Thorsen, Jonathan

AU - Rasmussen, Morten

AU - Eliasen, Anders

AU - Vinding, Rebecca Kofod

AU - Schoos, Ann-Marie Malby

AU - Brustad, Nicklas

AU - Sunde, Rikke Bjersand

AU - Bonnelykke, Klaus

AU - Chawes, Bo L.

AU - Stokholm, Jakob

AU - Bisgaard, Hans

PY - 2023

Y1 - 2023

N2 - Background. We hypothesized that insufficient intake of fish oil-derived omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) during pregnancy is a contributing factor to gastroenteritis in early childhood. We examined the effect of n-3 LCPUFA supplementation on gastroenteritis symptoms in the offspring's first 3 years of life. Methods. This was a double-blinded, randomized controlled trial whereby 736 mothers were administered n-3 LCPUFA or control from pregnancy week 24 until 1 week after birth. We measured the number of days with gastroenteritis, number of episodes with gastroenteritis, and the risk of having a gastroenteritis episode in the first 3 years of life. Results. A median reduction of 2.5 days with gastroenteritis (P = .018) was shown, corresponding to a 14% reduction in the n-3 LCPUFA group compared with controls in the first 3 years of life (P = .037). A reduction in the number of gastroenteritis episodes (P = .027) and a reduced risk of having an episode (hazard ratio, 0.80 [95% confidence interval, .66-.97]; P = .023) were also shown. Conclusions. Fish oil supplementation from the 24th week of pregnancy led to a reduction in the number of days and episodes with gastroenteritis symptoms in the first 3 years of life. The findings suggest n-3 LCPUFA supplementation as a preventive measure against gastrointestinal infections in early childhood.

AB - Background. We hypothesized that insufficient intake of fish oil-derived omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) during pregnancy is a contributing factor to gastroenteritis in early childhood. We examined the effect of n-3 LCPUFA supplementation on gastroenteritis symptoms in the offspring's first 3 years of life. Methods. This was a double-blinded, randomized controlled trial whereby 736 mothers were administered n-3 LCPUFA or control from pregnancy week 24 until 1 week after birth. We measured the number of days with gastroenteritis, number of episodes with gastroenteritis, and the risk of having a gastroenteritis episode in the first 3 years of life. Results. A median reduction of 2.5 days with gastroenteritis (P = .018) was shown, corresponding to a 14% reduction in the n-3 LCPUFA group compared with controls in the first 3 years of life (P = .037). A reduction in the number of gastroenteritis episodes (P = .027) and a reduced risk of having an episode (hazard ratio, 0.80 [95% confidence interval, .66-.97]; P = .023) were also shown. Conclusions. Fish oil supplementation from the 24th week of pregnancy led to a reduction in the number of days and episodes with gastroenteritis symptoms in the first 3 years of life. The findings suggest n-3 LCPUFA supplementation as a preventive measure against gastrointestinal infections in early childhood.

KW - Fish oil

KW - Gastroenteritis

KW - Pediatrics

KW - Pregnancy supplementation

U2 - 10.1093/infdis/jiab607

DO - 10.1093/infdis/jiab607

M3 - Journal article

C2 - 34927195

SN - 0022-1899

VL - 227

SP - 448

EP - 456

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 3

ER -

Supplementation With Fish Oil in Pregnancy Reduces Gastroenteritis in Early Childhood

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