135La as an auger-electron emitter for targeted internal radiotherapy

Jesper Fonslet, Boon Quan Lee, Thuy A. Tran, Mattia Siragusa, Mikael Jensen, Tibor Kibedi, Andrew E. Stuchbery, Gregory Severin*

*Corresponding author for this work

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    Abstract

    Introduction: 135La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, imaging characteristics, and dosimetry related to 135La therapy. Methods and Results: 135La was produced by 16.5 MeV proton irradiation of metallic natBa on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407 ± 19 MBq/µA (saturation activity, n = 3), and the radionuclidic purity was 98% at 20 h post irradiation. Chemical separation recovered > 98 % of the 135La with an effective molar activity of 70 ±20 GBq/µmol. To better assess cellular and organ dosimetry of this nuclide, we have recalculated the X-ray and Auger emission spectra using a Monte Carlo model accounting for effects of multiple vacancies during the Auger cascade. The generated Auger spectrum was used to recalculate cellular S-factors. Conclusion: 135La was produced with high specific activity, reactivity, radionuclidic purity, and yield. The emission spectrum and the dosimetry are favorable for internal radionuclide therapy. .
    Original languageEnglish
    Article number015026
    JournalPhysics in Medicine and Biology
    Volume63
    Issue number1
    Number of pages9
    ISSN0031-9155
    DOIs
    Publication statusPublished - 2018

    Keywords

    • Auger therapy
    • La-135
    • isotope production
    • lanthanum
    • radionuclide therapy

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