Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering

Jeremy Dinoro, Malachy Maher, Sepehr Talebian, Mahboubeh Jarfarkhani, Mehdi Mehrali, Gorka Orive, Javad Foroughi, Megan S. Lord, Alireza Dolatshahi-Pirouz*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Given their native-like biological properties, high growth factor retention capacity and porous nature, sulfated-polysaccharide-based scaffolds hold great promise for a number of tissue engineering applications. Specifically, as they mimic important properties of tissues such as bone and cartilage they are ideal for orthopaedic tissue engineering. Their biomimicry properties encompass important cell-binding motifs, native-like mechanical properties, designated sites for bone mineralization and strong growth factor binding and signalling capacity. Even so, scientists in the field have just recently begun to utilise them as building blocks for tissue engineering scaffolds. Most of these efforts have so far been directed towards in vitro studies, and for these reasons the clinical gap is still substantial. With this review paper, we have tried to highlight some of the important chemical, physical and biological features of sulfated-polysaccharides in relation to their chondrogenic and osteogenic inducing capacity. Additionally, their usage in various in vivo model systems is discussed. The clinical studies reviewed herein paint a promising picture heralding a brave new world for orthopaedic tissue engineering.
Original languageEnglish
Article number119214
JournalBiomaterials
Volume214
Number of pages21
ISSN0142-9612
DOIs
Publication statusPublished - 2019

Keywords

  • Sulfated polysaccharides
  • Biomaterials
  • Tissue engineering
  • Cartilage
  • Bone
  • Growth factors
  • Hydrogels

Cite this

Dinoro, J., Maher, M., Talebian, S., Jarfarkhani, M., Mehrali, M., Orive, G., Foroughi, J., Lord, M. S., & Dolatshahi-Pirouz, A. (2019). Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering. Biomaterials, 214, [119214]. https://doi.org/10.1016/j.biomaterials.2019.05.025