TY - JOUR
T1 - Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering
AU - Dinoro, Jeremy
AU - Maher, Malachy
AU - Talebian, Sepehr
AU - Jarfarkhani, Mahboubeh
AU - Mehrali, Mehdi
AU - Orive, Gorka
AU - Foroughi, Javad
AU - Lord, Megan S.
AU - Dolatshahi-Pirouz, Alireza
PY - 2019
Y1 - 2019
N2 - Given their native-like biological properties, high growth factor retention capacity and porous nature, sulfated-polysaccharide-based scaffolds hold great promise for a number of tissue engineering applications. Specifically, as they mimic important properties of tissues such as bone and cartilage they are ideal for orthopaedic tissue engineering. Their biomimicry properties encompass important cell-binding motifs, native-like mechanical properties, designated sites for bone mineralization and strong growth factor binding and signalling capacity. Even so, scientists in the field have just recently begun to utilise them as building blocks for tissue engineering scaffolds. Most of these efforts have so far been directed towards in vitro studies, and for these reasons the clinical gap is still substantial. With this review paper, we have tried to highlight some of the important chemical, physical and biological features of sulfated-polysaccharides in relation to their chondrogenic and osteogenic inducing capacity. Additionally, their usage in various in vivo model systems is discussed. The clinical studies reviewed herein paint a promising picture heralding a brave new world for orthopaedic tissue engineering.
AB - Given their native-like biological properties, high growth factor retention capacity and porous nature, sulfated-polysaccharide-based scaffolds hold great promise for a number of tissue engineering applications. Specifically, as they mimic important properties of tissues such as bone and cartilage they are ideal for orthopaedic tissue engineering. Their biomimicry properties encompass important cell-binding motifs, native-like mechanical properties, designated sites for bone mineralization and strong growth factor binding and signalling capacity. Even so, scientists in the field have just recently begun to utilise them as building blocks for tissue engineering scaffolds. Most of these efforts have so far been directed towards in vitro studies, and for these reasons the clinical gap is still substantial. With this review paper, we have tried to highlight some of the important chemical, physical and biological features of sulfated-polysaccharides in relation to their chondrogenic and osteogenic inducing capacity. Additionally, their usage in various in vivo model systems is discussed. The clinical studies reviewed herein paint a promising picture heralding a brave new world for orthopaedic tissue engineering.
KW - Sulfated polysaccharides
KW - Biomaterials
KW - Tissue engineering
KW - Cartilage
KW - Bone
KW - Growth factors
KW - Hydrogels
U2 - 10.1016/j.biomaterials.2019.05.025
DO - 10.1016/j.biomaterials.2019.05.025
M3 - Review
C2 - 31163358
SN - 0142-9612
VL - 214
JO - Biomaterials
JF - Biomaterials
M1 - 119214
ER -