TY - JOUR
T1 - Substantial molecular evolution and mutation rates in prolonged latent Mycobacterium tuberculosis infection in humans
AU - Lillebaek, Troels
AU - Norman, Anders
AU - Rasmussen, Erik Michael
AU - Marvig, Rasmus Lykke
AU - Bek Folkvardsen, Dorte
AU - Bengaard Andersen, Åse
AU - Jelsbak, Lars
PY - 2016
Y1 - 2016
N2 - The genome of Mycobacterium tuberculosis (Mtb) of latently infected individuals may hold the key to understanding the processes that lead to reactivation and progression to clinical disease. We report here analysis of pairs of Mtb isolates from putative prolonged latent TB cases. We identified two confirmed cases, and used whole genome sequencing to investigate the mutational processes that occur over decades in latent Mtb. We found an estimated mutation rate between 0.2 and 0.3 over 33 years, suggesting that latent Mtb accumulates mutations at rates similar to observations from cases of active disease.
AB - The genome of Mycobacterium tuberculosis (Mtb) of latently infected individuals may hold the key to understanding the processes that lead to reactivation and progression to clinical disease. We report here analysis of pairs of Mtb isolates from putative prolonged latent TB cases. We identified two confirmed cases, and used whole genome sequencing to investigate the mutational processes that occur over decades in latent Mtb. We found an estimated mutation rate between 0.2 and 0.3 over 33 years, suggesting that latent Mtb accumulates mutations at rates similar to observations from cases of active disease.
KW - Latent infection
KW - Within-host evolution
KW - Mutation rate
KW - Genome sequencing
KW - Pathogen evolution
U2 - 10.1016/j.ijmm.2016.05.017
DO - 10.1016/j.ijmm.2016.05.017
M3 - Journal article
C2 - 27296510
SN - 1438-4221
VL - 306
SP - 580
EP - 585
JO - International Journal of Medical Microbiology
JF - International Journal of Medical Microbiology
IS - 7
ER -
