Sub-100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces

Maria Dimaki*, Mark Holm Olsen, Noemi Rozlosnik, Winnie E. Svendsen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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This paper presents a novel microfluidic chip for upconcentration of sub-100 nm nanoparticles in a flow using electrical forces generated by a DC or AC field. Two electrode designs were optimized using COMSOL Multiphysics and tested using particles with sizes as low as 47 nm. We show how inclined electrodes with a zig-zag three-tooth configuration in a channel of 20 µm width are the ones generating the highest gradient and therefore the largest force. The design, based on AC dielectrophoresis, was shown to upconcentrate sub-100 nm particles by a factor of 11 using a flow rate of 2-25 µL/h. We present theoretical and experimental results and discuss how the chip design can easily be massively parallelized in order to increase throughput by a factor of at least 1250.
Original languageEnglish
Article number866
Issue number6
Number of pages14
Publication statusPublished - 2022


  • Dielectrophoresis
  • Upconcentration
  • Microfluids
  • Nanoparticles


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