Structure–Activity Relationship Study Based on Autoinducing Peptide (AIP) from Dog Pathogen S. schleiferi

Bengt H. Gless, Pai Peng, Katja Desiree Pedersen, Charlotte Held Gotfredsen, Hanne Ingmer, Christian A. Olsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Herein,an effective protocol for solid-phase synthesis of peptidethiolactones by concomitant ring closure and cleavage from the solidsupport is reported. The strategy was applied for mapping the importanceof the structural features in S. schleiferi AIP (5) by performing an alanine scan and truncation of this naturalcompound. This furnished some of the most potent inhibitors of accessorygene regulator (agr)-I in the human pathogen S. aureus reported to date.
Original languageEnglish
JournalORGANIC LETTERS
Volume19
Issue number19
Pages (from-to)5276-5279
ISSN1523-7060
DOIs
Publication statusPublished - 2017

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