Structure and partitioning of bacterial DNA: determined by a balance of competion and expansion forces?

C. L. Woldringh; Peter Ruhdal Jensen; H. V. Westerhoff

doi:10.1016/0378-1097(95)00243-X

Structure and partitioning of bacterial DNA: determined by a balance of competion and expansion forces?

C. L. Woldringh, Peter Ruhdal Jensen, H. V. Westerhoff

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The mechanisms that determine chromosome structure and chromosome partitioning in bacteria are largely unknown. Here we discuss two hypotheses: (i) the structure of the Escherichia coli nucleoid is determined by DNA binding proteins and DNA supercoiling, representing a compaction force on the one hand, and by the coupled transcription/translation/translocation of plasma membrane and cell wall proteins, representing an expansion force on the other hand; (ii) the two forces are important for the partitioning process of chromosomes.

Original language	English
Journal	F E M S Microbiology Letters
Volume	131
Issue number	3
Pages (from-to)	235-242
Number of pages	8
ISSN	0378-1097
DOIs	https://doi.org/10.1016/0378-1097(95)00243-X
Publication status	Published - 1995

Keywords

Chromosomes, Bacterial
DNA Replication
DNA, Bacterial
DNA, Superhelical
DNA-Binding Proteins
Escherichia coli
Models, Genetic
Nucleic Acid Conformation
MICROBIOLOGY
ESCHERICHIA-COLI
GENE-EXPRESSION
TOPOISOMERASE-I
CELL-DIVISION
CHROMOSOME
PROTEIN
TRANSCRIPTION
MUTANTS
EXPORT
CYCLE
DNA SUPERCOILING
NUCLEOID STRUCTURE
COUPLED TRANSCRIPTION TRANSLATION
PROTEIN TRANSLOCATION
DNA supercoiling
Nucleoid structure
Coupled transcription/translation
Protein translocation
CELL WALL
CHROMOSOME STRUCTURE
DNA BINDING PROTEINS
PLASMA MEMBRANE
SUPERCOILING
TRANSLATION
TRANSLOCATION
Facultatively Anaerobic Gram-Negative Rods Eubacteria Bacteria Microorganisms (Bacteria, Eubacteria, Microorganisms) - Enterobacteriaceae [06702] Escherichia coli
10010, Comparative biochemistry
10052, Biochemistry methods - Nucleic acids, purines and pyrimidines
10062, Biochemistry studies - Nucleic acids, purines and pyrimidines
10064, Biochemistry studies - Proteins, peptides and amino acids
10300, Replication, transcription, translation
10504, Biophysics - Methods and techniques
10506, Biophysics - Molecular properties and macromolecules
13012, Metabolism - Proteins, peptides and amino acids
13014, Metabolism - Nucleic acids, purines and pyrimidines
30500, Morphology and cytology of bacteria
31000, Physiology and biochemistry of bacteria
31500, Genetics of bacteria and viruses
32300, Microbiological ultrastructure
Biochemistry and Molecular Biophysics
Cell Biology
Genetics
Metabolism
Methods and Techniques
Molecular Genetics
Physiology

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@article{4635089ded984f398a59d03db8711297,

title = "Structure and partitioning of bacterial DNA: determined by a balance of competion and expansion forces?",

abstract = "The mechanisms that determine chromosome structure and chromosome partitioning in bacteria are largely unknown. Here we discuss two hypotheses: (i) the structure of the Escherichia coli nucleoid is determined by DNA binding proteins and DNA supercoiling, representing a compaction force on the one hand, and by the coupled transcription/translation/translocation of plasma membrane and cell wall proteins, representing an expansion force on the other hand; (ii) the two forces are important for the partitioning process of chromosomes.",

keywords = "Chromosomes, Bacterial, DNA Replication, DNA, Bacterial, DNA, Superhelical, DNA-Binding Proteins, Escherichia coli, Models, Genetic, Nucleic Acid Conformation, MICROBIOLOGY, ESCHERICHIA-COLI, GENE-EXPRESSION, TOPOISOMERASE-I, CELL-DIVISION, CHROMOSOME, PROTEIN, TRANSCRIPTION, MUTANTS, EXPORT, CYCLE, DNA SUPERCOILING, NUCLEOID STRUCTURE, COUPLED TRANSCRIPTION TRANSLATION, PROTEIN TRANSLOCATION, DNA supercoiling, Nucleoid structure, Coupled transcription/translation, Protein translocation, CELL WALL, CHROMOSOME STRUCTURE, DNA BINDING PROTEINS, PLASMA MEMBRANE, SUPERCOILING, TRANSLATION, TRANSLOCATION, Facultatively Anaerobic Gram-Negative Rods Eubacteria Bacteria Microorganisms (Bacteria, Eubacteria, Microorganisms) - Enterobacteriaceae [06702] Escherichia coli, 10010, Comparative biochemistry, 10052, Biochemistry methods - Nucleic acids, purines and pyrimidines, 10062, Biochemistry studies - Nucleic acids, purines and pyrimidines, 10064, Biochemistry studies - Proteins, peptides and amino acids, 10300, Replication, transcription, translation, 10504, Biophysics - Methods and techniques, 10506, Biophysics - Molecular properties and macromolecules, 13012, Metabolism - Proteins, peptides and amino acids, 13014, Metabolism - Nucleic acids, purines and pyrimidines, 30500, Morphology and cytology of bacteria, 31000, Physiology and biochemistry of bacteria, 31500, Genetics of bacteria and viruses, 32300, Microbiological ultrastructure, Biochemistry and Molecular Biophysics, Cell Biology, Genetics, Metabolism, Methods and Techniques, Molecular Genetics, Physiology",

author = "Woldringh, {C. L.} and Jensen, {Peter Ruhdal} and Westerhoff, {H. V.}",

year = "1995",

doi = "10.1016/0378-1097(95)00243-X",

language = "English",

volume = "131",

pages = "235--242",

journal = "F E M S Microbiology Letters",

issn = "0378-1097",