Structural landscape of immunoglobulin lambda light chains

Anna Chailyan, Davide Cirillo, Paolo Marcatili, Anna Tramontano

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review


The immunoglobulin lambda isotype family is present in nearly all vertebrates and plays a primary role in the human immune system. Despite its importance, few if any systematic studies have been performed to identify, as it has been the case for kappa and heavy chains, a set of structural conformations adopted by the loops forming its Antigen Binding Site (ABSs). The aim of this work is to perform such analysis on the vast majority of known antibody lambda chains by means of an integrative approach of bioinformatics (structural superpositions and sequence alignments), machine learning (clustering, random forest) and statistical techniques.

Original languageEnglish
Title of host publicationACM-BCB 2010 International Conference on Bioinformatics and Computational Biology
PublisherAssociation for Computing Machinery
Publication date2010
ISBN (Print)9781450304382
Publication statusPublished - 2010
Externally publishedYes
EventInternational Conference On Bioinformatics and Computational Biology (ACM-BCB) - Niagara Falls, NY, United States
Duration: 2 Aug 20104 Aug 2010


ConferenceInternational Conference On Bioinformatics and Computational Biology (ACM-BCB)
Country/TerritoryUnited States
CityNiagara Falls, NY


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