Structural landscape of immunoglobulin lambda light chains

Anna Chailyan; Davide Cirillo; Paolo Marcatili; Anna Tramontano

doi:10.1145/1854776.1854901

Structural landscape of immunoglobulin lambda light chains

Anna Chailyan, Davide Cirillo, Paolo Marcatili, Anna Tramontano

University of Rome La Sapienza

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

The immunoglobulin lambda isotype family is present in nearly all vertebrates and plays a primary role in the human immune system. Despite its importance, few if any systematic studies have been performed to identify, as it has been the case for kappa and heavy chains, a set of structural conformations adopted by the loops forming its Antigen Binding Site (ABSs). The aim of this work is to perform such analysis on the vast majority of known antibody lambda chains by means of an integrative approach of bioinformatics (structural superpositions and sequence alignments), machine learning (clustering, random forest) and statistical techniques.

Original language	English
Title of host publication	ACM-BCB 2010 International Conference on Bioinformatics and Computational Biology
Publisher	Association for Computing Machinery
Publication date	2010
Pages	651-652
ISBN (Print)	9781450304382
DOIs	https://doi.org/10.1145/1854776.1854901
Publication status	Published - 2010
Externally published	Yes
Event	International Conference On Bioinformatics and Computational Biology (ACM-BCB) - Niagara Falls, NY, United States Duration: 2 Aug 2010 → 4 Aug 2010

Conference

Conference	International Conference On Bioinformatics and Computational Biology (ACM-BCB)
Country/Territory	United States
City	Niagara Falls, NY
Period	02/08/2010 → 04/08/2010

Access to Document

10.1145/1854776.1854901

OpenUrl availability

Full text

Cite this

@inproceedings{8b5f87b508704a25845054230851ec02,

title = "Structural landscape of immunoglobulin lambda light chains",

abstract = "The immunoglobulin lambda isotype family is present in nearly all vertebrates and plays a primary role in the human immune system. Despite its importance, few if any systematic studies have been performed to identify, as it has been the case for kappa and heavy chains, a set of structural conformations adopted by the loops forming its Antigen Binding Site (ABSs). The aim of this work is to perform such analysis on the vast majority of known antibody lambda chains by means of an integrative approach of bioinformatics (structural superpositions and sequence alignments), machine learning (clustering, random forest) and statistical techniques.",

author = "Anna Chailyan and Davide Cirillo and Paolo Marcatili and Anna Tramontano",

year = "2010",

doi = "10.1145/1854776.1854901",

language = "English",

isbn = "9781450304382",

pages = "651--652",

booktitle = "ACM-BCB 2010 International Conference on Bioinformatics and Computational Biology",

publisher = "Association for Computing Machinery",

address = "United States",

note = "International Conference On Bioinformatics and Computational Biology (ACM-BCB) ; Conference date: 02-08-2010 Through 04-08-2010",

}

Chailyan, A, Cirillo, D, Marcatili, P & Tramontano, A 2010, Structural landscape of immunoglobulin lambda light chains. in ACM-BCB 2010 International Conference on Bioinformatics and Computational Biology. Association for Computing Machinery, pp. 651-652, International Conference On Bioinformatics and Computational Biology (ACM-BCB), Niagara Falls, NY, United States, 02/08/2010. https://doi.org/10.1145/1854776.1854901

Structural landscape of immunoglobulin lambda light chains. / Chailyan, Anna; Cirillo, Davide; Marcatili, Paolo et al.
ACM-BCB 2010 International Conference on Bioinformatics and Computational Biology. Association for Computing Machinery, 2010. p. 651-652.

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

TY - GEN

T1 - Structural landscape of immunoglobulin lambda light chains

AU - Chailyan, Anna

AU - Cirillo, Davide

AU - Marcatili, Paolo

AU - Tramontano, Anna

PY - 2010

Y1 - 2010

N2 - The immunoglobulin lambda isotype family is present in nearly all vertebrates and plays a primary role in the human immune system. Despite its importance, few if any systematic studies have been performed to identify, as it has been the case for kappa and heavy chains, a set of structural conformations adopted by the loops forming its Antigen Binding Site (ABSs). The aim of this work is to perform such analysis on the vast majority of known antibody lambda chains by means of an integrative approach of bioinformatics (structural superpositions and sequence alignments), machine learning (clustering, random forest) and statistical techniques.

AB - The immunoglobulin lambda isotype family is present in nearly all vertebrates and plays a primary role in the human immune system. Despite its importance, few if any systematic studies have been performed to identify, as it has been the case for kappa and heavy chains, a set of structural conformations adopted by the loops forming its Antigen Binding Site (ABSs). The aim of this work is to perform such analysis on the vast majority of known antibody lambda chains by means of an integrative approach of bioinformatics (structural superpositions and sequence alignments), machine learning (clustering, random forest) and statistical techniques.

U2 - 10.1145/1854776.1854901

DO - 10.1145/1854776.1854901

M3 - Article in proceedings

SN - 9781450304382

SP - 651

EP - 652

BT - ACM-BCB 2010 International Conference on Bioinformatics and Computational Biology

PB - Association for Computing Machinery

T2 - International Conference On Bioinformatics and Computational Biology (ACM-BCB)

Y2 - 2 August 2010 through 4 August 2010

ER -

Structural landscape of immunoglobulin lambda light chains

Abstract

Conference

Access to Document

OpenUrl availability

Fingerprint

Cite this