Abstract
Background: Family 7 cellulases exhibit significant hydrolytic potential in cellulose degradation.
Results: We report the Heterobasidion irregulare GH7 structure and compare it with other GH7 cellobiohydrolases with simulation.
Conclusion: H. irregulare Cel7A exhibits intermediate dynamical and structural properties between Phanerochaete chrysosporium
Cel7D and Hypocrea jecorina Cel7A.
Significance: These results highlight regions of family 7 cellobiohydrolases important for carbohydrate processivity and association-dissociation
rates on cellulose.
Original language | English |
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Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 8 |
Pages (from-to) | 5861-5872 |
Number of pages | 12 |
ISSN | 0021-9258 |
DOIs | |
Publication status | Published - 2013 |
Externally published | Yes |
Keywords
- Biofuel
- Cellulase
- Crystallography
- Glycoside hydrolases
- Molecular dynamics
- Heterobasidion annosum
- Hypocrea jecorina
- Phanerochaete chrysosporium
- Trichoderma reesei
- Cellobiohydrolase