Structural basis for cyclophellitol inhibition of a β-glucosidase

Tracey M. Gloster, Robert Madsen, Gideon J. Davies

Research output: Contribution to journalJournal articleResearchpeer-review


The structural basis for b-glucosidase inhibition by cyclophellitol is demonstrated using X-ray crystallography, enzyme kinetics and mass spectrometry. The natural product was shown to bind by a covalent bond in the active site of the enzyme. This bond is formed by ring-opening of the epoxide in cyclophellitol with a carboxylic acid from the enzyme.
Original languageEnglish
JournalOrganic and Biomolecular Chemistry
Issue number3
Pages (from-to)444-446
Publication statusPublished - 2007


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