Streptococcus agalactiae Serotype IV in Humans and Cattle, Northern Europe

Ulrike Lyhs, Laura Kulkas, Jorgen Katholm, Karin Persson Waller, Kerttu Saha, Richard J. Tomusk, Ruth N. Zadoks

    Research output: Contribution to journalJournal articleResearchpeer-review

    184 Downloads (Pure)

    Abstract

    Streptococcus agalactiae is an emerging pathogen of nonpregnant human adults worldwide and a reemerging pathogen of dairy cattle in parts of Europe. To learn more about interspecies transmission of this bacterium, we compared contemporaneously collected isolates from humans and cattle in Finland and Sweden. Multilocus sequence typing identified 5 sequence types (STs) (ST1, 8, 12, 23, and 196) shared across the 2 host species, suggesting possible interspecies transmission. More than 54% of the isolates belonged to those STs. Molecular serotyping and pilus island typing of those isolates did not differentiate between populations isolated from different host species. Isolates from humans and cattle differed in lactose fermentation, which is encoded on the accessory genome and represents an adaptation to the bovine mammary gland. Serotype IV-ST196 isolates were obtained from multiple dairy herds in both countries. Cattle may constitute a previously unknown reservoir of this strain.
    Original languageEnglish
    JournalEmerging Infectious Diseases
    Volume22
    Issue number12
    Pages (from-to)2097-2103
    Number of pages7
    ISSN1080-6040
    DOIs
    Publication statusPublished - 2016

    Keywords

    • IMMUNOLOGY
    • INFECTIOUS
    • GROUP-B STREPTOCOCCUS
    • NONPREGNANT ADULTS
    • ANTIMICROBIAL RESISTANCE
    • MASTITIS PATHOGENS
    • MULTIPLEX PCR
    • UNITED-STATES
    • DAIRY HERDS
    • BOVINE
    • COLONIZATION
    • DISEASE
    • Europe
    • Streptococcus agalactiae
    • bacteria
    • bovine mastitis
    • cattle
    • host specificity
    • human
    • molecular epidemiology
    • zoonoses

    Cite this

    Lyhs, U., Kulkas, L., Katholm, J., Waller, K. P., Saha, K., Tomusk, R. J., & Zadoks, R. N. (2016). Streptococcus agalactiae Serotype IV in Humans and Cattle, Northern Europe. Emerging Infectious Diseases , 22(12), 2097-2103. https://doi.org/10.3201/eid2212.151447
    Lyhs, Ulrike ; Kulkas, Laura ; Katholm, Jorgen ; Waller, Karin Persson ; Saha, Kerttu ; Tomusk, Richard J. ; Zadoks, Ruth N. / Streptococcus agalactiae Serotype IV in Humans and Cattle, Northern Europe. In: Emerging Infectious Diseases . 2016 ; Vol. 22, No. 12. pp. 2097-2103.
    @article{e594d7fed872491d8e654af5d52f6bab,
    title = "Streptococcus agalactiae Serotype IV in Humans and Cattle, Northern Europe",
    abstract = "Streptococcus agalactiae is an emerging pathogen of nonpregnant human adults worldwide and a reemerging pathogen of dairy cattle in parts of Europe. To learn more about interspecies transmission of this bacterium, we compared contemporaneously collected isolates from humans and cattle in Finland and Sweden. Multilocus sequence typing identified 5 sequence types (STs) (ST1, 8, 12, 23, and 196) shared across the 2 host species, suggesting possible interspecies transmission. More than 54{\%} of the isolates belonged to those STs. Molecular serotyping and pilus island typing of those isolates did not differentiate between populations isolated from different host species. Isolates from humans and cattle differed in lactose fermentation, which is encoded on the accessory genome and represents an adaptation to the bovine mammary gland. Serotype IV-ST196 isolates were obtained from multiple dairy herds in both countries. Cattle may constitute a previously unknown reservoir of this strain.",
    keywords = "IMMUNOLOGY, INFECTIOUS, GROUP-B STREPTOCOCCUS, NONPREGNANT ADULTS, ANTIMICROBIAL RESISTANCE, MASTITIS PATHOGENS, MULTIPLEX PCR, UNITED-STATES, DAIRY HERDS, BOVINE, COLONIZATION, DISEASE, Europe, Streptococcus agalactiae, bacteria, bovine mastitis, cattle, host specificity, human, molecular epidemiology, zoonoses",
    author = "Ulrike Lyhs and Laura Kulkas and Jorgen Katholm and Waller, {Karin Persson} and Kerttu Saha and Tomusk, {Richard J.} and Zadoks, {Ruth N.}",
    year = "2016",
    doi = "10.3201/eid2212.151447",
    language = "English",
    volume = "22",
    pages = "2097--2103",
    journal = "Emerging Infectious Diseases (Print Edition)",
    issn = "1080-6040",
    publisher = "Centers for Disease Control and Prevention",
    number = "12",

    }

    Lyhs, U, Kulkas, L, Katholm, J, Waller, KP, Saha, K, Tomusk, RJ & Zadoks, RN 2016, 'Streptococcus agalactiae Serotype IV in Humans and Cattle, Northern Europe', Emerging Infectious Diseases , vol. 22, no. 12, pp. 2097-2103. https://doi.org/10.3201/eid2212.151447

    Streptococcus agalactiae Serotype IV in Humans and Cattle, Northern Europe. / Lyhs, Ulrike; Kulkas, Laura; Katholm, Jorgen; Waller, Karin Persson; Saha, Kerttu; Tomusk, Richard J.; Zadoks, Ruth N.

    In: Emerging Infectious Diseases , Vol. 22, No. 12, 2016, p. 2097-2103.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Streptococcus agalactiae Serotype IV in Humans and Cattle, Northern Europe

    AU - Lyhs, Ulrike

    AU - Kulkas, Laura

    AU - Katholm, Jorgen

    AU - Waller, Karin Persson

    AU - Saha, Kerttu

    AU - Tomusk, Richard J.

    AU - Zadoks, Ruth N.

    PY - 2016

    Y1 - 2016

    N2 - Streptococcus agalactiae is an emerging pathogen of nonpregnant human adults worldwide and a reemerging pathogen of dairy cattle in parts of Europe. To learn more about interspecies transmission of this bacterium, we compared contemporaneously collected isolates from humans and cattle in Finland and Sweden. Multilocus sequence typing identified 5 sequence types (STs) (ST1, 8, 12, 23, and 196) shared across the 2 host species, suggesting possible interspecies transmission. More than 54% of the isolates belonged to those STs. Molecular serotyping and pilus island typing of those isolates did not differentiate between populations isolated from different host species. Isolates from humans and cattle differed in lactose fermentation, which is encoded on the accessory genome and represents an adaptation to the bovine mammary gland. Serotype IV-ST196 isolates were obtained from multiple dairy herds in both countries. Cattle may constitute a previously unknown reservoir of this strain.

    AB - Streptococcus agalactiae is an emerging pathogen of nonpregnant human adults worldwide and a reemerging pathogen of dairy cattle in parts of Europe. To learn more about interspecies transmission of this bacterium, we compared contemporaneously collected isolates from humans and cattle in Finland and Sweden. Multilocus sequence typing identified 5 sequence types (STs) (ST1, 8, 12, 23, and 196) shared across the 2 host species, suggesting possible interspecies transmission. More than 54% of the isolates belonged to those STs. Molecular serotyping and pilus island typing of those isolates did not differentiate between populations isolated from different host species. Isolates from humans and cattle differed in lactose fermentation, which is encoded on the accessory genome and represents an adaptation to the bovine mammary gland. Serotype IV-ST196 isolates were obtained from multiple dairy herds in both countries. Cattle may constitute a previously unknown reservoir of this strain.

    KW - IMMUNOLOGY

    KW - INFECTIOUS

    KW - GROUP-B STREPTOCOCCUS

    KW - NONPREGNANT ADULTS

    KW - ANTIMICROBIAL RESISTANCE

    KW - MASTITIS PATHOGENS

    KW - MULTIPLEX PCR

    KW - UNITED-STATES

    KW - DAIRY HERDS

    KW - BOVINE

    KW - COLONIZATION

    KW - DISEASE

    KW - Europe

    KW - Streptococcus agalactiae

    KW - bacteria

    KW - bovine mastitis

    KW - cattle

    KW - host specificity

    KW - human

    KW - molecular epidemiology

    KW - zoonoses

    U2 - 10.3201/eid2212.151447

    DO - 10.3201/eid2212.151447

    M3 - Journal article

    VL - 22

    SP - 2097

    EP - 2103

    JO - Emerging Infectious Diseases (Print Edition)

    JF - Emerging Infectious Diseases (Print Edition)

    SN - 1080-6040

    IS - 12

    ER -