Streptococcus agalactiae Serotype IV in Humans and Cattle, Northern Europe

Ulrike Lyhs, Laura Kulkas, Jorgen Katholm, Karin Persson Waller, Kerttu Saha, Richard J. Tomusk, Ruth N. Zadoks

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    Abstract

    Streptococcus agalactiae is an emerging pathogen of nonpregnant human adults worldwide and a reemerging pathogen of dairy cattle in parts of Europe. To learn more about interspecies transmission of this bacterium, we compared contemporaneously collected isolates from humans and cattle in Finland and Sweden. Multilocus sequence typing identified 5 sequence types (STs) (ST1, 8, 12, 23, and 196) shared across the 2 host species, suggesting possible interspecies transmission. More than 54% of the isolates belonged to those STs. Molecular serotyping and pilus island typing of those isolates did not differentiate between populations isolated from different host species. Isolates from humans and cattle differed in lactose fermentation, which is encoded on the accessory genome and represents an adaptation to the bovine mammary gland. Serotype IV-ST196 isolates were obtained from multiple dairy herds in both countries. Cattle may constitute a previously unknown reservoir of this strain.
    Original languageEnglish
    JournalEmerging Infectious Diseases
    Volume22
    Issue number12
    Pages (from-to)2097-2103
    Number of pages7
    ISSN1080-6040
    DOIs
    Publication statusPublished - 2016

    Keywords

    • IMMUNOLOGY
    • INFECTIOUS
    • GROUP-B STREPTOCOCCUS
    • NONPREGNANT ADULTS
    • ANTIMICROBIAL RESISTANCE
    • MASTITIS PATHOGENS
    • MULTIPLEX PCR
    • UNITED-STATES
    • DAIRY HERDS
    • BOVINE
    • COLONIZATION
    • DISEASE
    • Europe
    • Streptococcus agalactiae
    • bacteria
    • bovine mastitis
    • cattle
    • host specificity
    • human
    • molecular epidemiology
    • zoonoses

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