Streamline tractography for 3D mapping of axon bundle organization in one MRI voxel using ultra-high resolution synchrotron radiation imaging

Hans Martin Kjer, Mariam Andersson, Yi He, Marie Louise Elkjaer, Alexandra Pacureanu, Zsolt Illes, Bente Pakkenberg, Anders Bjorholm Dahl, Vedrana Andersen Dahl, Tim Bjørn Dyrby

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

We present an efficient image analysis pipeline that enables us to reveal white matter organization in high-resolution 3D non-MRI structural datasets, in cases where a strict image segmentation is not required nor possible. We apply the method to a synchrotron X-ray holographic tomography scan from a healthy mouse sample, and show the organization of axon bundles in a region covering parts of the corpus callosum and the cingulum. The method has a potential to improve our general understanding of white matter organization and our ability to generate realistic phantoms for validation of microstructure modelling from low-resolution diffusion MRI scans.
Original languageEnglish
Title of host publicationProceedings of 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages3
PublisherThe International Society for Magnetic Resonance in Medicine
Publication date2020
Pages1-3
Publication statusPublished - 2020
Event2020 ISMRM & SMRT Virtual Conference & Exhibition - Online
Duration: 8 Aug 202014 Aug 2020

Conference

Conference2020 ISMRM & SMRT Virtual Conference & Exhibition
LocationOnline
Period08/08/202014/08/2020
SeriesProceedings of 2020 ISMRM & SMRT Virtual Conference & Exhibition

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