Strategies for Optical Trapping in Biological Samples: Aiming at Microrobotic Surgeons

Ada-Ioana Bunea*, Jesper Glückstad

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Optical trapping and manipulation of objects down to the ˚Angstrom level has revolutionized research at the smallest scales in all natural sciences. The flexibility of optical trapping methods facilitates real-time monitoring of the dynamics of biological processes in model systems and even in living cells. Different optical trapping and manipulation approaches allow displacement of nanostructures with subnanometer precision and force measurements with femtonewton precision. Due to inherent constraints of optical methods, most optical trapping experiments are performed in water or simple aqueous solutions. However, in recent years, there is an ever-growing interest of shiftingfromsimpleaqueousmediatowardsmorebiologically-relevantmedia. Precise optical trapping and manipulation, combined with state-of-the-art microfabrication, will enable the development of microrobotic “surgeons” with tremendous potential for biomedical and microengineering applications. This review introduces the basics of optical trapping and discusses its applications for biological samples, with focus on trapping in biological media and strategies for overcoming the challenges of optical manipulation in complex environments as a stepping-stone for microrobotic “surgeons.”
Original languageEnglish
Article number1800227
JournalLaser & Photonics Reviews
Number of pages17
ISSN1863-8880
DOIs
Publication statusPublished - 2019

Keywords

  • Beam‐shaping
  • Light Robotics
  • Microrobots
  • Optical manipulation
  • Optical Trapping

Cite this

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title = "Strategies for Optical Trapping in Biological Samples: Aiming at Microrobotic Surgeons",
abstract = "Optical trapping and manipulation of objects down to the ˚Angstrom level has revolutionized research at the smallest scales in all natural sciences. The flexibility of optical trapping methods facilitates real-time monitoring of the dynamics of biological processes in model systems and even in living cells. Different optical trapping and manipulation approaches allow displacement of nanostructures with subnanometer precision and force measurements with femtonewton precision. Due to inherent constraints of optical methods, most optical trapping experiments are performed in water or simple aqueous solutions. However, in recent years, there is an ever-growing interest of shiftingfromsimpleaqueousmediatowardsmorebiologically-relevantmedia. Precise optical trapping and manipulation, combined with state-of-the-art microfabrication, will enable the development of microrobotic “surgeons” with tremendous potential for biomedical and microengineering applications. This review introduces the basics of optical trapping and discusses its applications for biological samples, with focus on trapping in biological media and strategies for overcoming the challenges of optical manipulation in complex environments as a stepping-stone for microrobotic “surgeons.”",
keywords = "Beam‐shaping, Light Robotics, Microrobots, Optical manipulation, Optical Trapping",
author = "Ada-Ioana Bunea and Jesper Gl{\"u}ckstad",
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doi = "10.1002/lpor.201800227",
language = "English",
journal = "Laser & Photonics Reviews",
issn = "1863-8880",
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}

Strategies for Optical Trapping in Biological Samples: Aiming at Microrobotic Surgeons. / Bunea, Ada-Ioana; Glückstad, Jesper.

In: Laser & Photonics Reviews, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Strategies for Optical Trapping in Biological Samples: Aiming at Microrobotic Surgeons

AU - Bunea, Ada-Ioana

AU - Glückstad, Jesper

PY - 2019

Y1 - 2019

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AB - Optical trapping and manipulation of objects down to the ˚Angstrom level has revolutionized research at the smallest scales in all natural sciences. The flexibility of optical trapping methods facilitates real-time monitoring of the dynamics of biological processes in model systems and even in living cells. Different optical trapping and manipulation approaches allow displacement of nanostructures with subnanometer precision and force measurements with femtonewton precision. Due to inherent constraints of optical methods, most optical trapping experiments are performed in water or simple aqueous solutions. However, in recent years, there is an ever-growing interest of shiftingfromsimpleaqueousmediatowardsmorebiologically-relevantmedia. Precise optical trapping and manipulation, combined with state-of-the-art microfabrication, will enable the development of microrobotic “surgeons” with tremendous potential for biomedical and microengineering applications. This review introduces the basics of optical trapping and discusses its applications for biological samples, with focus on trapping in biological media and strategies for overcoming the challenges of optical manipulation in complex environments as a stepping-stone for microrobotic “surgeons.”

KW - Beam‐shaping

KW - Light Robotics

KW - Microrobots

KW - Optical manipulation

KW - Optical Trapping

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