Strategies for glucose control in people with type 1 diabetes

Dimitri Boiroux (Invited author), Daniel Aaron Finan (Invited author), John Bagterp Jørgensen (Invited author), Niels Kjølstad Poulsen (Invited author), Henrik Madsen (Invited author)

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Abstract

In this paper we apply a robust feedforward-feedback control strategy to people with type 1 diabetes. The feedforward controller consists of a bolus calculator which compensates the disturbance coming from meals. The feedback controller is based on a linearized description of the model describing the patient. We minimize the risk of hypoglycemia by introducing a time-varying glucose setpoint based on the announced meal size and the physiological model of the patient. The simulation results are based on a virtual patient simulated by the Hovorka model. They include the cases where the insulin sensitivity changes, and mismatches in meal estimation. They demonstrate that the designed controller is able to achieve offset-free control when the insulin sensitivity change, and that having a time-varying reference signal enables more robust control of blood glucose in the cases where the meal size is known, but also when the ingested meal does not match the announced one.
Original languageEnglish
Title of host publicationProceedings of the 18th World Congress of the International Federation of Automatic Control (IFAC)
Publication date2011
DOIs
Publication statusPublished - 2011
Event18th World Congress of the International Federation of Automatic Control - Milano, Italy
Duration: 28 Aug 20112 Sep 2011
Conference number: 18
http://www.ifac2011.org/

Conference

Conference18th World Congress of the International Federation of Automatic Control
Number18
Country/TerritoryItaly
CityMilano
Period28/08/201102/09/2011
Internet address

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