Strand misalignments lead to quasipalindrome correction

V. van Noort, Peder Worning, David Ussery, W.A. Rosche, R.R. Sinden

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Quasipalindromes, or imperfect inverted repeats, undergo spontaneous mutation to more-perfect inverted repeats. These mutations have been observed in many organisms, ranging from bacteria to humans, where they are associated with mutations leading to disease. We determined the relative frequency of quasi palindromes and perfect palindromes in more than 100 sequenced prokaryotic genomes. In nearly all cases, perfect palindromes were relatively more frequent than quasipalindromes, suggesting that quasipalindrome correction is a general mechanism for mutation in prokaryotes.
    Original languageEnglish
    JournalTrends in Genetics
    Volume19
    Issue number7
    Pages (from-to)365-369
    ISSN0168-9525
    Publication statusPublished - 2003

    Cite this

    van Noort, V., Worning, P., Ussery, D., Rosche, W. A., & Sinden, R. R. (2003). Strand misalignments lead to quasipalindrome correction. Trends in Genetics, 19(7), 365-369.