Strain-Release Driven Cycloadditions for Rapid Construction of Functionalized Pyridines and Amino Alcohols

Sebastian Clementson, Alessio Radaelli, Kasper Fjelbye, David Ackland Tanner*, Mikkel Jessing

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

This paper describes the development of a new variant of stereoselective strain-release driven reactions (formal homo [3 + 2] dipolar cycloadditions) which utilize housane (1) to construct functionalized amino alcohols and pyridine-substituted cyclopentanes in two to three steps from simple and easily available building blocks (nitrones and pyridine N-oxides respectively).
Original languageEnglish
JournalOrganic Letters
Volume21
Issue number12
Pages (from-to)4763-4766
Number of pages4
ISSN1523-7060
DOIs
Publication statusPublished - 2019

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