Storage Telemetry of Radionuclide Tracers by Implantable Thermoluminescent Dosimeters

J. Bojsen, U. Møller, Poul Christensen, Jørgen Emil Lippert

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    Abstract

    A storage telemetrical method using thermoluminescent (TL) dosimeters for long-term measurements of incorporated radioactive substances in unrestrained rats has been developed. The system has been used in combination with radiotelemetrical registration of the circadian temperature rhythm. By sequential replacement of double TL dosimeters (60 mg, CaSO4:Dy) through an implanted silicon tube, the concentration of different radionuclides can be determined over long periods. The persistence of the circadian temperature rhythm indicates that the animals were unaffected by the experimental conditions. The relative uncertainty of the dosimeter system and the temperature transmitter is approximately +/- 2% (SD) at 5 mR exposures and +/- 0.05 degrees C, respectively. The weight of the system in total is 5.7 g. Disappearance studies (36-48 h) have been performed with the beta-emitters, 32P nad 42K, in subcutaneous tissues and tumor tissue. This TL method permits the repetition of an experiment on the same rat several times, and thereby avoids errors due to biological variations between animals.
    Original languageEnglish
    JournalAmerican Journal of Physiology (Consolidated)
    Volume233
    Issue number6
    Pages (from-to)E479-E482
    ISSN0002-9513
    Publication statusPublished - 1977

    Cite this

    Bojsen, J., Møller, U., Christensen, P., & Lippert, J. E. (1977). Storage Telemetry of Radionuclide Tracers by Implantable Thermoluminescent Dosimeters. American Journal of Physiology (Consolidated), 233(6), E479-E482.