Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma

Research output: Contribution to journalJournal article – Annual report year: 2010Researchpeer-review

Without internal affiliation

  • Author: Zibellini, S.

  • Author: Capello, D.

  • Author: Forconi, F.

  • Author: Marcatili, Paolo

    University of Rome La Sapienza

  • Author: Rossi, D.

  • Author: Rattotti, S.

  • Author: Franceschetti, S.

  • Author: Sozzi, E.

  • Author: Cencini, E.

  • Author: Marasca, R.

  • Author: Baldini, Luca

  • Author: Tucci, Alessandra

  • Author: Bertoni, Francesco

  • Author: Passamonti, Francesco

  • Author: Orlandi, Ester

  • Author: Varettoni, Marzia

  • Author: Merli, Michele

  • Author: Rizzi, Silvia

  • Author: Gattei, Valter

  • Author: Tramontano, Anna

  • Author: Paulli, Marco

  • Author: Gaidano, Gianluca

  • Author: Arcaini, Luca

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Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified:
i) “SMZL-specific subsets” (n=5), composed only of 12 SMZL (9 HCV- from our series); ii) “Non-Hodgkin’s lymphoma-like subsets” (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) “CLL-like subsets” (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCVunrelated epitopes or an antigenic trigger common to other indolent lymphomas.
Original languageEnglish
JournalHaematologica
Volume95
Issue number10
Pages (from-to)1792-1796
ISSN0390-6078
DOIs
Publication statusPublished - 2010
Externally publishedYes

Bibliographical note

This is an open-access paper.

CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • splenic marginal zone lymphoma, B cell receptor, immunoglobulin genes, hepatitis C virus

ID: 59268841